NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity (Q27678249)

1

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Jinwoo Ahn

2

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Mithun Mitra

3

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Chang-Hyeock Byeon

4

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Kamil Hercík

5

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Jozef Hritz

6

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Lisa M Charlton

7

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Judith G Levin

describes a project that uses

8

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language of work or name

English

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publication date

2013

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published in

Nature Communications

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volume

4

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page(s)

1890

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ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3674325/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1

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Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

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An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model

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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

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All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition

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APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.

29 September 2017

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29 September 2017

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Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A

29 September 2017

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Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.

29 September 2017

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Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.

29 September 2017

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Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

29 September 2017

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Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.

29 September 2017

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APOBEC2 is a monomer in solution: implications for APOBEC3G models

29 September 2017

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APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.

29 September 2017

1 reference

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Fast flexible modeling of RNA structure using internal coordinates.

29 September 2017

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APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

The current structural and functional understanding of APOBEC deaminases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

APOBEC proteins and intrinsic resistance to HIV-1 infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Vpr.A3A chimera inhibits HIV replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

APOBEC3 proteins inhibit human LINE-1 retrotransposition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Determining the structures of large proteins and protein complexes by NMR.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Complementary function of the two catalytic domains of APOBEC3G.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325

27 November 2018

Identifiers

DOI

10.1038/NCOMMS2883

1 reference

Dimensions Publication ID

2005374

ADS bibcode

2013NatCo...4.1890B

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1007409494

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2005374

1 reference

1 reference

1 reference