Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange (Q27681830)

1

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Qi Sun

2

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R Nathan Daniels

3

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DeMarco Camper

4

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J Phillip Kennedy

5

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Jason Phan

6

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Edward T Olejniczak

7

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Taekyu Lee

8

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Alex G Waterson

9

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Olivia W Rossanese

Proceedings of the National Academy of Sciences of the United States of America

10

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language of work or name

English

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publication date

4 March 2014

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published in

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volume

111

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issue

9

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page(s)

3401-6

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cites work

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling

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Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation

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Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

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Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway

29 September 2017

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Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange

29 September 2017

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1315798111

Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24550516

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1315798111

1 reference

1910345

ADS bibcode

2014PNAS..111.3401B

0 references

1910345

1 reference

1 reference

1 reference