Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation (Q27687338)

Christoph Thomas

series ordinal

2

1 reference

K.Christopher Garcia

series ordinal

3

1 reference

Gideon Schreiber

series ordinal

4

1 reference

publication date

November 2012

1 reference

published in

Immunological Reviews

1 reference

volume

250

1 reference

issue

1

1 reference

page(s)

317-34

1 reference

Ubiquitination-mediated regulation of interferon responses

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1 reference

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Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

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A diverse range of gene products are effectors of the type I interferon antiviral response

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Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

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Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

20 March 2017

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UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

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SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor

20 March 2017

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The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding

20 March 2017

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Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site

20 March 2017

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The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution

20 March 2017

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The crystal structure of human interferon beta at 2.2-A resolution

20 March 2017

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Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography

20 March 2017

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Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor

20 March 2017

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The human interferon alpha/beta receptor: characterization and molecular cloning

20 March 2017

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Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA

20 March 2017

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UBP43 (USP18) specifically removes ISG15 from conjugated proteins

20 March 2017

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20 March 2017

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The receptor of the type I interferon family

20 March 2017

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20 March 2017

Mechanisms of type-I- and type-II-interferon-mediated signalling

21 January 2018

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Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha

20 March 2017

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor

20 March 2017

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Role of type I IFNs in pulmonary complications of Pneumocystis murina infection

20 March 2017

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Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

20 March 2017

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Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules

20 March 2017

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Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

7 April 2017

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Type I interferons in host defense

7 April 2017

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The JAK-STAT pathway at twenty

7 April 2017

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Interferons as biomarkers and effectors: lessons learned from animal models.

29 September 2017

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Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS.

29 September 2017

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The interferons and their receptors--distribution and regulation

29 September 2017

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Interferon-stimulated genes and their antiviral effector functions

29 September 2017

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Membrane mechanisms for signal transduction: the coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complexes

29 September 2017

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Evolutionary genetic dissection of human interferons

29 September 2017

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Binding and activity of all human alpha interferon subtypes

29 September 2017

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USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response

29 September 2017

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Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2

29 September 2017

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Structural variants of IFNα preferentially promote antiviral functions

29 September 2017

1 reference

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Stochastic receptor expression determines cell fate upon interferon treatment

29 September 2017

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Interferon: current status and future prospects in cancer therapy

29 September 2017

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Beta interferon suppresses the development of experimental cerebral malaria

29 September 2017

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Interferon-stimulated gene 15 and the protein ISGylation system

29 September 2017

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Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2

29 September 2017

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Major differences in the responses of primary human leukocyte subsets to IFN-beta.

29 September 2017

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Differential gene expression and translational approaches to identify biomarkers of interferon beta activity in multiple sclerosis

29 September 2017

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Molecular basis of cytokine receptor activation

29 September 2017

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NMR mapping of the IFNAR1-EC binding site on IFNalpha2 reveals allosteric changes in the IFNAR2-EC binding site

29 September 2017

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Biochemical monitoring of the early endocytic traffic of the type I interferon receptor

29 September 2017

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Receptor density is key to the alpha2/beta interferon differential activities.

29 September 2017

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Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

29 September 2017

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Creation of interferon-alpha8 mutants with amino acid substitutions against interferon-alpha receptor-2 binding sites using phage display system and evaluation of their biologic properties

29 September 2017

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Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis

29 September 2017

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29 September 2017

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Upregulation of a small subset of genes drives type I interferon-induced antiviral memory

29 September 2017

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An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities

29 September 2017

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Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta

29 September 2017

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Determination of the two-dimensional interaction rate constants of a cytokine receptor complex

29 September 2017

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Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

29 September 2017

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The yin and yang of type I interferon activity in bacterial infection

29 September 2017

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Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

29 September 2017

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Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar1.

29 September 2017

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Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection

29 September 2017

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Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

29 September 2017

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Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor

29 September 2017

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Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors

29 September 2017

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Full house: 12 receptors for 27 cytokines

29 September 2017

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Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.

29 September 2017

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Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2.

29 September 2017

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Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

29 September 2017

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Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry

29 September 2017

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Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking

29 September 2017

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29 September 2017

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Fast transient cytokine-receptor interactions monitored in real time by reflectometric interference spectroscopy

29 September 2017

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New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface

29 September 2017

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Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.

29 September 2017

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Interaction affinity between cytokine receptor components on the cell surface

29 September 2017

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Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta

29 September 2017

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Ligand-induced association of the type I interferon receptor components

29 September 2017

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The differential activity of interferon-α subtypes is consistent among distinct target genes and cell types

29 September 2017

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Probing protein conformations by in situ non-covalent fluorescence labeling.

2 June 2018

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The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling

2 June 2018

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Differential receptor subunit affinities of type I interferons govern differential signal activation.

2 June 2018

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Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors

2 June 2018

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TYK2 activity promotes ligand-induced IFNAR1 proteolysis

2 June 2018

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Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation

2 June 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Monitoring the dynamics of ligand-receptor complexes on model membranes

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Variations in the unstructured C-terminal tail of interferons contribute to differential receptor binding and biological activity

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12 December 2020

Probing 2-dimensional protein-protein interactions on model membranes

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12 December 2020

Interferon at 50: new molecules, new potential, new (and old) questions

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12 December 2020

Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain

1 reference

12 December 2020

Mechanisms for regulation of cellular responsiveness to human IFN-beta1a

1 reference

12 December 2020

IFN-alpha subtypes differentially affect human T cell motility

1 reference

12 December 2020

Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2

1 reference

12 December 2020

Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity

1 reference

12 December 2020