The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction (Q27727807)

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13 June 2020

Aina E Cohen

5

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13 June 2020

author name string

Ying Wu

1

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13 June 2020

Christopher O Barnes

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13 June 2020

Maria DeLucia

4

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13 June 2020

Angela M Gronenborn

6

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13 June 2020

Jinwoo Ahn

7

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13 June 2020

Guillermo Calero

8

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Nature Structural & Molecular Biology

13 June 2020

language of work or name

1 reference

October 2016

0 references

published in

1 reference

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13 June 2020

volume

23

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13 June 2020

issue

10

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13 June 2020

page(s)

933-940

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Suppression of APOBEC3-mediated restriction of HIV-1 by Vif

13 June 2020

cites work

1 reference

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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

25 May 2017

1 reference

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Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing

25 May 2017

1 reference

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Structural basis of lentiviral subversion of a cellular protein degradation pathway

25 May 2017

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25 May 2017

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Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair

25 May 2017

1 reference

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Linking Crystallographic Model and Data Quality

25 May 2017

1 reference

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The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

25 May 2017

1 reference

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

25 May 2017

1 reference

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

25 May 2017

1 reference

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Structure and function of WD40 domain proteins

25 May 2017

1 reference

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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

25 May 2017

1 reference

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Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

25 May 2017

1 reference

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HIV-1 accessory proteins--ensuring viral survival in a hostile environment

25 May 2017

1 reference

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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

25 May 2017

1 reference

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Enzymatic capture of an extrahelical thymine in the search for uracil in DNA

25 May 2017

1 reference

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DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

25 May 2017

1 reference

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

25 May 2017

1 reference

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Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

NMR structure of the HIV-1 regulatory protein VPR

25 May 2017

1 reference

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Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest

25 May 2017

1 reference

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Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

25 May 2017

1 reference

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HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins

25 May 2017

1 reference

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Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors

29 September 2017

1 reference

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HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.

29 September 2017

1 reference

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Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.

29 September 2017

1 reference

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Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV accessory proteins versus host restriction factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

β-TrCP dependency of HIV-1 Vpu-induced downregulation of CD4 and BST-2/tetherin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

The role of HIV-1 Vpr in promoting the infection of nondividing cells and in cell cycle arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV DNA is heavily uracilated, which protects it from autointegration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

APOBEC proteins and intrinsic resistance to HIV-1 infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Vpr-mediated incorporation of UNG2 into HIV-1 particles is required to modulate the virus mutation rate and for replication in macrophages

29 September 2017

1 reference

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Isolation of human immunodeficiency virus type 1 cores: retention of Vpr in the absence of p6(gag).

29 September 2017

1 reference

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Molecular biology of the human immunodeficiency virus accessory proteins

29 September 2017

1 reference

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The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Vpr overcomes macrophage-specific restriction of HIV-1 Env expression and virion production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5385928

Complex Evolutionary History of Primate LentiviralvprGenes

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.3284

Considerations for the refinement of low-resolution crystal structures

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.3284

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.3284

31 March 2020

Identifiers

DOI

10.1038/NSMB.3284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27571178%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27571178%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference