HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest. (Q35837172)

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scientific article published in June 2015

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English	HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.	scientific article published in June 2015

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16 February 2020

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest (English)

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16 February 2020

Mohammad Reze Aghasadeghi

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16 February 2020

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Bizhan Romani

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Nima Shaykh Baygloo

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Elham Allahbakhshi

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1 June 2015

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Journal of Biological Chemistry

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17380-17389

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CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

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Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0.

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A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.

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Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1

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Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

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Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

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Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.

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Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0

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Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

1 reference

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A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae

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HSV-1 ICP0: paving the way for viral replication

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Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection

1 reference

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The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

1 reference

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Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

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Identifiers

10.1074/JBC.M115.641522

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16 February 2020

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16 February 2020

1 reference

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16 February 2020

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