Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab. (Q27852191)

13 November 2016

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28 February 2020

title

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab (English)

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28 February 2020

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Esther Martínez-Martínez

3

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28 February 2020

Mariano Provencio

6

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28 February 2020

Luis Alvarez-Vallina

7

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28 February 2020

Laura Sanz

8

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28 February 2020

1

Irene Guijarro-Muñoz

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28 February 2020

5

Clara Salas

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28 February 2020

author name string

Antonio Sánchez

2

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28 February 2020

Jose M García

4

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28 February 2020

publication date

12 April 2013

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28 February 2020

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28 February 2020

volume

30

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28 February 2020

issue

2

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28 February 2020

page(s)

572

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The cancer biomarker problem

28 February 2020

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Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases

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EPHB4 and survival of colorectal cancer patients.

21 January 2018

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Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth

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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

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The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth

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Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

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Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth

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The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

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PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity

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Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

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DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo

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Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer

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Coexpression of ephrin-Bs and their receptors in colon carcinoma

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Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression

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The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome

21 January 2018

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Paradoxes of the EphB4 receptor in cancer

21 January 2018

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The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway

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The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

21 January 2018

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EphB receptor activity suppresses colorectal cancer progression

21 January 2018

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EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target

21 January 2018

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Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand

21 January 2018

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Eph receptors and ephrins in cancer: bidirectional signalling and beyond

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Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer

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21 January 2018

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Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase.

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12 December 2020

Gene expression in colorectal cancer

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12 December 2020

Costly cancer drugs trigger proposals to modify clinical trial design

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23579861%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 February 2020

1018021223

0 references

2 references

13 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23579861%20AND%20SRC:MED&resulttype=core&format=json