Structural Maturation of HIV-1 Reverse Transcriptase-A Metamorphic Solution to Genomic Instability (Q28074527)

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27 September 2016

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10

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Creative Commons Attribution 4.0 International

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260

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27 September 2016

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April 2022 Public Data File from Crossref

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

20 March 2017

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29 September 2017

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Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase.

29 September 2017

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29 September 2017

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Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy.

29 September 2017

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A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses

29 September 2017

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The p66 immature precursor of HIV-1 reverse transcriptase.

29 September 2017

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Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission

29 September 2017

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Protein-mediated antagonism between HIV reverse transcriptase ligands nevirapine and MgATP.

29 September 2017

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Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

29 September 2017

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Efavirenz enhances HIV-1 gag processing at the plasma membrane through Gag-Pol dimerization

29 September 2017

1 reference

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Implications of 3D domain swapping for protein folding, misfolding and function.

29 September 2017

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Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556

29 September 2017

1 reference

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Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain.

29 September 2017

1 reference

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29 September 2017

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Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity

29 September 2017

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Selection of nonnucleoside reverse transcriptase inhibitor-associated mutations in HIV-1 subtype C: evidence of etravirine cross-resistance

29 September 2017

1 reference

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Proteins that switch folds

29 September 2017

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Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

29 September 2017

1 reference

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The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site

29 September 2017

1 reference

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Formation of the tRNALys packaging complex in HIV-1.

29 September 2017

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Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: lessons for inhibitor design from a cluster analysis of many crystal structures.

29 September 2017

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Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase

29 September 2017

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Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

29 September 2017

1 reference

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Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

29 September 2017

1 reference

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MAPPIT (MAmmalian Protein-Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cells

29 September 2017

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Novel HIV-1 reverse transcriptase inhibitors.

29 September 2017

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Nucleocapsid protein function in early infection processes

29 September 2017

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Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.

29 September 2017

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Myristoylation is required for human immunodeficiency virus type 1 Gag-Gag multimerization in mammalian cells

29 September 2017

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Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance

29 September 2017

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Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

29 September 2017

1 reference

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Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

29 September 2017

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TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

29 September 2017

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The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in rep

29 September 2017

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Basics of the virology of HIV-1 and its replication

29 September 2017

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Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain

29 September 2017

1 reference

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High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations

29 September 2017

1 reference

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Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer

29 September 2017

1 reference

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Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions

29 September 2017

1 reference

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Lethal mutagenesis of HIV.

29 September 2017

1 reference

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Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.

29 September 2017

1 reference

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Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

29 September 2017

1 reference

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The unfolding story of three-dimensional domain swapping.

29 September 2017

1 reference

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Role of residues in the tryptophan repeat motif for HIV-1 reverse transcriptase dimerization

29 September 2017

1 reference

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Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules

29 September 2017

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Protein folding and three-dimensional domain swapping: a strained relationship?

29 September 2017

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Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase

29 September 2017

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Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy

29 September 2017

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Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase

29 September 2017

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An open and closed case for all polymerases.

29 September 2017

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Characterization of a folding intermediate from HIV-1 ribonuclease H

29 September 2017

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Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization

29 September 2017

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The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.

29 September 2017

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Analysis of the nucleic acid annealing activities of nucleocapsid protein from HIV-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: a two step process

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

29 September 2017

The retroviral enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

HIV reverse transcriptase structure-function relationships

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

29 September 2017

Prediction of beta-turns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

In vitro resistance selection with doravirine (MK-1439), a novel nonnucleoside reverse transcriptase inhibitor with distinct mutation development pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Homodimerization of the p51 subunit of HIV-1 reverse transcriptase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Kinetics of association and dissociation of HIV-1 reverse transcriptase subunits

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Isolated HIV-1 core is active for reverse transcription.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Human immunodeficiency virus type 1 (HIV-1) recombinant reverse transcriptase. Asymmetry in p66 subunits of the p66/p66 homodimer

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Cleavage of the HIV-1 p66 reverse transcriptase/RNase H by the p9 protease in vitro generates active p15 RNase H

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Catalytic properties of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Stabilization and activation of recombinant human immunodeficiency virus-1 reverse transcriptase-P66

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Analysis of the backbone dynamics of the ribonuclease H domain of the human immunodeficiency virus reverse transcriptase using 15N relaxation measurements

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

The accuracy of reverse transcriptase from HIV-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5086598

Error thresholds and the constraints to RNA virus evolution

20 June 2018

1 reference

Glutamic residue 438 within the protease-sensitive subdomain of HIV-1 reverse transcriptase is critical for heterodimer processing in viral particles.

21 January 2018

1 reference

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

21 January 2018

1 reference

Biochemistry. Metamorphic proteins

21 January 2018

1 reference

Effects of efavirenz binding on the subunit equilibria of HIV-1 reverse transcriptase

21 January 2018

1 reference

Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication

21 January 2018

1 reference

A captured folding intermediate involved in dimerization and domain-swapping of GB1.

21 January 2018

1 reference

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

21 January 2018

1 reference

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

21 January 2018

1 reference

Insertion of a peptide from MuLV RT into the connection subdomain of HIV-1 RT results in a functionally active chimeric enzyme in monomeric conformation

21 January 2018

1 reference

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

21 January 2018

1 reference

The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs

21 January 2018

1 reference

A reexamination of the propensities of amino acids towards a particular secondary structure: classification of amino acids based on their chemical structure.

21 January 2018

1 reference

In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor

21 January 2018

1 reference

NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.

21 January 2018

1 reference

Backbone dynamics of the RNase H domain of HIV-1 reverse transcriptase

21 January 2018

1 reference

A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility

21 January 2018

1 reference

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V

21 January 2018

1 reference

21 January 2018

1 reference

Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group

21 January 2018

1 reference

Factors affecting the dimerization of the p66 form of HIV-1 reverse transcriptase

21 January 2018

1 reference

12 December 2020

Structure/function studies of HIV-1(1) reverse transcriptase: dimerization-defective mutant L289K

1 reference

12 December 2020

Relationship between enzyme activity and dimeric structure of recombinant HIV-1 reverse transcriptase

1 reference

12 December 2020

Characterization of the dimerization process of HIV-1 reverse transcriptase heterodimer using intrinsic protein fluorescence

1 reference

12 December 2020

Kinetic Analysis of Four HIV-1 Reverse Transcriptase Enzymes Mutated in the Primer Grip Region of p66

1 reference

12 December 2020