Cancer stem cell metabolism: a potential target for cancer therapy (Q28079045)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27825361%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

review article

2 references

5 July 2021

Cancer stem cell metabolism: a potential target for cancer therapy (English)

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27 March 2020

1 reference

8 February 2021

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5 July 2021

neoplastic stem cells

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object of statement has role

inferred from title

glutaminolysis

subject heading

object named as

Glutaminolysis

1 reference

PubMed publication ID

1

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27 March 2020

author name string

Kedar Deshpande

2

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27 March 2020

Frank Arfuso

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27 March 2020

Philip Newsholme

4

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27 March 2020

Arun Dharmarajan

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27 March 2020

language of work or name

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8 November 2016

6 references

3 April 2019

12 October 2019

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27 March 2020

8 February 2021

5 July 2021

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3 April 2019

12 October 2019

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27 March 2020

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27 March 2020

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cites work

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells

20 March 2017

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Energy metabolism in tumor cells

20 March 2017

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

20 March 2017

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

20 March 2017

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Hypoxia-inducible expression of tumor-associated carbonic anhydrases

20 March 2017

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mTOR regulation of autophagy

20 March 2017

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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

7 April 2017

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Hallmarks of cancer stem cell metabolism.

7 April 2017

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3D-QSAR AND CONTOUR MAP ANALYSIS OF TARIQUIDAR ANALOGUES AS MULTIDRUG RESISTANCE PROTEIN-1 (MRP1) INHIBITORS.

29 September 2017

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Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

29 September 2017

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MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

29 September 2017

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Systemic Administration of Small Interfering RNA Targeting Human Nestin Inhibits Pancreatic Cancer Cell Proliferation and Metastasis.

29 September 2017

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29 September 2017

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29 September 2017

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Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells

29 September 2017

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

29 September 2017

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Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition

29 September 2017

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Clinical impact of the Warburg effect in gastrointestinal cancer (review).

29 September 2017

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Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells.

29 September 2017

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Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells

29 September 2017

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29 September 2017

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The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

29 September 2017

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29 September 2017

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Energy metabolism characterization of a novel cancer stem cell-like line 3AB-OS.

29 September 2017

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29 September 2017

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Understanding and targeting cancer stem cells: therapeutic implications and challenges

29 September 2017

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Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

29 September 2017

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BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

29 September 2017

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29 September 2017

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Effective elimination of cancer stem cells by a novel drug combination strategy

29 September 2017

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29 September 2017

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Targeting the metabolic microenvironment of tumors

29 September 2017

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Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

29 September 2017

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29 September 2017

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Polyphenols counteract tumor cell chemoresistance conferred by multidrug resistance proteins

29 September 2017

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From tumor cell metabolism to tumor immune escape

29 September 2017

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Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis

29 September 2017

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Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression

29 September 2017

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Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

29 September 2017

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Proteomic analysis reveals Warburg effect and anomalous metabolism of glutamine in pancreatic cancer cells

29 September 2017

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mTOR signaling in disease

29 September 2017

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Targeting cancer metabolism: a therapeutic window opens

29 September 2017

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Metabolic alterations in cancer cells and therapeutic implications

29 September 2017

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Gefitinib induces apoptosis in human glioma cells by targeting Bad phosphorylation

29 September 2017

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CD44-targeting for antitumor drug delivery: a new SN-38-hyaluronan bioconjugate for locoregional treatment of peritoneal carcinomatosis

29 September 2017

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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

29 September 2017

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Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

29 September 2017

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Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells

29 September 2017

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Glutamine addiction: a new therapeutic target in cancer

29 September 2017

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Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells

29 September 2017

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Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model

29 September 2017

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Glucose metabolism in cancer cells

29 September 2017

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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

29 September 2017

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Hypoxia inducible factors in cancer stem cells

29 September 2017

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Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

29 September 2017

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A side population of cells from a human pancreatic carcinoma cell line harbors cancer stem cell characteristics

29 September 2017

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Targeting stem cells-clinical implications for cancer therapy

29 September 2017

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CD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumours

29 September 2017

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Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

29 September 2017

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Is tumor growth sustained by rare cancer stem cells or dominant clones?

29 September 2017

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

29 September 2017

1 reference

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Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials

29 September 2017

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Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells

29 September 2017

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Acid treatment of melanoma cells selects for invasive phenotypes

29 September 2017

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Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML).

29 September 2017

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Persistence of side population cells with high drug efflux capacity in pancreatic cancer

29 September 2017

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CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway.

29 September 2017

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Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

ABCG2: determining its relevance in clinical drug resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Targeted therapy for cancer stem cells: the patched pathway and ABC transporters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Detection of tumor stem cell markers in pancreatic carcinoma cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Glucose metabolism and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Role of mitochondria as the gardens of cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Causes and effects of heterogeneous perfusion in tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

The relevance of tumour pH to the treatment of malignant disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Cancer Metabolism: Is Glutamine Sweeter than Glucose?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

2 June 2018

Are cancer cells acidic?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Targeting metabolism to induce cell death in cancer cells and cancer stem cells

2 June 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12943-016-0555-X

What makes cancer stem cell markers different?

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12943-016-0555-X

The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12943-016-0555-X

Nucleotide-binding sites of the heterodimeric LmrCD ABC-multidrug transporter of Lactococcus lactis are asymmetric.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12943-016-0555-X

Phenylbutyrate inhibits the invasive properties of prostate and breast cancer cell lines in the sea urchin embryo basement membrane invasion assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12943-016-0555-X

Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12943-016-0555-X

Hypoxia-induced acidification causes mitoxantrone resistance not mediated by drug transporters in human breast cancer cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Cell cycle analysis of bovine cultured somatic cells by flow cytometry

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5101698

Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate

27 November 2018

1 reference

12 December 2020

ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia

1 reference

12 December 2020

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice

1 reference

12 December 2020

P-Glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with P-glycoprotein-positive acute myeloid leukemia

1 reference

12 December 2020

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

1 reference

12 December 2020

10.1186/S12943-016-0555-X

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27825361%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 March 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12943-016-0555-x

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27825361%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

27825361

2 references