Targeting cancer metabolism: a therapeutic window opens (Q37924094)

25 August 2017

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title

Targeting cancer metabolism: a therapeutic window opens (English)

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25 August 2017

Matthew G Vander Heiden

series ordinal

1

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25 August 2017

31 August 2011

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Nature Reviews Drug Discovery

25 August 2017

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25 August 2017

10

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25 August 2017

671-684

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25 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrd3504

25 August 2017

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31 March 2020

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31 March 2020

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The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate

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31 March 2020

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The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

31 March 2020

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The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

31 March 2020

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

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Nampt: linking NAD biology, metabolism and cancer

31 March 2020

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Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

31 March 2020

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Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

31 March 2020

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The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

31 March 2020

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NAMPT in regulated NAD biosynthesis and its pivotal role in human metabolism.

31 March 2020

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An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

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IDH1 and IDH2 mutations in gliomas

31 March 2020

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Recurring mutations found by sequencing an acute myeloid leukemia genome

31 March 2020

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

31 March 2020

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

31 March 2020

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

31 March 2020

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

31 March 2020

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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

31 March 2020

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

31 March 2020

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

31 March 2020

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

31 March 2020

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

31 March 2020

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

31 March 2020

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Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

31 March 2020

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

31 March 2020

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Alternative fuel--another role for p53 in the regulation of metabolism

31 March 2020

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

31 March 2020

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

31 March 2020

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

31 March 2020

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Glutamine metabolism in lymphocytes of the rat.

31 March 2020

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

31 March 2020

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

31 March 2020

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Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice

31 March 2020

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Does G6PD deficiency protect against cancer? A critical review

31 March 2020

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Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?

31 March 2020

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Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect

31 March 2020

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The Action of Pteroylglutamic Conjugates on Man.

31 March 2020

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Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

31 March 2020

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Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists

31 March 2020

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Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma

31 March 2020

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Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum

31 March 2020

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Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects

31 March 2020

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E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children

31 March 2020

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Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

31 March 2020

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

31 March 2020

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

31 March 2020

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Fatty acid synthase as a potential therapeutic target in cancer

31 March 2020

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ATP citrate lyase is an important component of cell growth and transformation

31 March 2020

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Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

31 March 2020

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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

31 March 2020

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Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

31 March 2020

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

31 March 2020

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Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

31 March 2020

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A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.

31 March 2020

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12 December 2020

Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor

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12 December 2020

Hyperglycaemia: link to excess mortality

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12 December 2020

PET imaging of prostate cancer with 11C-acetate

1 reference

12 December 2020

Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism.

1 reference

12 December 2020

Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose

1 reference

12 December 2020

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

1 reference

12 December 2020

Reduction of G1 phase duration and enhancement of c-myc gene expression in HeLa cells at hypergravity

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12 December 2020

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4

1 reference

12 December 2020

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis

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12 December 2020

Metabolic genes in cancer: their roles in tumor progression and clinical implications

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12 December 2020

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

12 December 2020

Genotoxic exposure is associated with alterations in glucose uptake and metabolism.

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12 December 2020

Identifiers

DOI

10.1038/NRD3504

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25 August 2017

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PubMed ID

21878982