The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy (Q28088784)

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English	The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy	scientific article

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scholarly article

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Europe PubMed Central

The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy (English)

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author name string

T. A. Waldmann

1

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language of work or name

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publication date

March 2015

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Cancer Immunology Research

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3

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3

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219-27

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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

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Interleukin-15 biology and its therapeutic implications in cancer

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Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation

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Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans

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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

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Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

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Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

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IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha

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The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control

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The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID

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Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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Signaling in lymphocyte activation

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Molecular pathways: interleukin-15 signaling in health and in cancer

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The interleukin-2 receptor.

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Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Targeted cytokines for cancer immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Rapid regression of chemotherapy refractory lymphocyte predominant Hodgkin's disease after administration of rituximab (anti CD 20 mono- clonal antibody) and interleukin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780

27 November 2018

IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of R24 monoclonal antibody and low-dose interleukin 2 for malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fueling regulation: IL-2 keeps CD4+ Treg cells fit

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-15 Mediates Anti-tumor Effects after Cyclophosphamide Injection of Tumor-Bearing Mice and Enhances Adoptive Immunotherapy: The Potential Role of NK Cell Subpopulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/25736261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/2326-6066.CIR-15-0009

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Sitelinks

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