Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain (Q28116593)

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11 February 2020

title

Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain (English)

2 references

4 January 2017

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11 February 2020

0 references

1 reference

microtubule associated protein tau

1 reference

intracellular distribution of mitochondria

GOA release 2020-03-11

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GOA release 2020-03-11

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4

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11 February 2020

Jennifer Luebke

6

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11 February 2020

Tara L Spires-Jones

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Matthew P Frosch

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11 February 2020

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Bradley T Hyman

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11 February 2020

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Robert M Koffie

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11 February 2020

Katherine J Kopeikina

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object named as

Katherine J Kopeikina

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11 February 2020

3

Rose Pitstick

2 references

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2

George A Carlson

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11 February 2020

author name string

Alan Peters

5

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11 February 2020

language of work or name

English

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publication date

18 August 2011

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The American Journal of Pathology

11 February 2020

published in

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volume

179

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issue

4

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11 February 2020

page(s)

2071-2082

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11 February 2020

1 reference

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The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility

20 March 2017

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20 March 2017

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Mitochondrial fusion and fission in cell life and death

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1 reference

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

20 March 2017

1 reference

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

20 March 2017

1 reference

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Differential regulation of dynein and kinesin motor proteins by tau

20 March 2017

1 reference

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1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

7 April 2017

1 reference

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The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

7 April 2017

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

7 April 2017

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Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

7 April 2017

1 reference

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

7 April 2017

1 reference

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

7 April 2017

1 reference

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29 September 2017

The many faces of tau

1 reference

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Characterization of genetically targeted neuron types in the zebrafish optic tectum

29 September 2017

1 reference

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

29 September 2017

1 reference

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Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study

29 September 2017

1 reference

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Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers

29 September 2017

1 reference

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Preparation and characterization of neurotoxic tau oligomers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181340

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

29 September 2017

1 reference

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Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

29 September 2017

1 reference

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Alzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease

29 September 2017

1 reference

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Correlative microscopy of densely labeled projection neurons using neural tracers

29 September 2017

1 reference

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A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.

29 September 2017

1 reference

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The Alzheimer's disease mitochondrial cascade hypothesis

29 September 2017

1 reference

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Caspase activation precedes and leads to tangles

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1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

29 September 2017

1 reference

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Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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29 September 2017

1 reference

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The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

29 September 2017

1 reference

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29 September 2017

1 reference

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Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: neurofilaments attenuate tau-mediated neurite instability

29 September 2017

1 reference

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29 September 2017

1 reference

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Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

29 September 2017

1 reference

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29 September 2017

1 reference

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The axonal transport of mitochondria.

29 September 2017

1 reference

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29 September 2017

1 reference

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

29 September 2017

1 reference

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Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

2 June 2018

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Frequency of stages of Alzheimer-related lesions in different age categories

2 June 2018

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Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

2 June 2018

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Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.

27 November 2018

1 reference

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Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau.

27 November 2018

1 reference

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Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

27 November 2018

1 reference

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Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.

27 November 2018

1 reference

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Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181340

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

27 November 2018

1 reference

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181340

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3181340

10.1016/J.AJPATH.2011.07.004

27 November 2018

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release_xax2y66myngr5ld56vwwbb4hry

11 February 2020

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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11 February 2020

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4 January 2017