Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. (Q48592298)

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19 January 2020

title

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology (English)

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19 January 2020

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Yu Deng

1

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19 January 2020

Leonid Tarassishin

2

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19 January 2020

Verena Kallhoff

3

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19 January 2020

Erica Peethumnongsin

4

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19 January 2020

Ling Wu

5

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19 January 2020

Yue-Ming Li

6

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19 January 2020

Hui Zheng

7

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19 January 2020

language of work or name

English

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publication date

1 April 2006

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19 January 2020

published in

Journal of Neuroscience

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19 January 2020

volume

26

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19 January 2020

issue

14

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19 January 2020

page(s)

3845-3854

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

19 January 2020

cites work

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

12 December 2020

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

1 reference

12 December 2020

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

12 December 2020

The role of presenilins in Alzheimer's disease

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

12 December 2020

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

1 reference

12 December 2020

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

12 December 2020

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

1 reference

12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

12 December 2020

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

1 reference

12 December 2020

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

1 reference

12 December 2020

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

1 reference

12 December 2020

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

12 December 2020

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

1 reference

12 December 2020

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

12 December 2020

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 reference

12 December 2020

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

12 December 2020

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

12 December 2020

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

12 December 2020

The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms

1 reference

12 December 2020

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

12 December 2020

A cell biological perspective on Alzheimer's disease

1 reference

12 December 2020

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

12 December 2020

Notch1 functions as a tumor suppressor in mouse skin

1 reference

12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

12 December 2020

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

12 December 2020

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

1 reference

12 December 2020

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

1 reference

12 December 2020

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

12 December 2020

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

1 reference

12 December 2020

Gamma-secretase: proteasome of the membrane?

1 reference

12 December 2020

The gamma-secretase complex: machinery for intramembrane proteolysis

1 reference

12 December 2020

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

1 reference

12 December 2020

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

1 reference

12 December 2020

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

1 reference

12 December 2020

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

1 reference

12 December 2020

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

1 reference

12 December 2020

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

12 December 2020

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

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12 December 2020

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

12 December 2020

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

1 reference

12 December 2020

10.1523/JNEUROSCI.5384-05.2006

Identifiers

DOI

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19 January 2020

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19 January 2020

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