The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network (Q34825957)

4 August 2017

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title

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network (English)

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4 August 2017

Lindsey D Mayo

1

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PubMed ID

12217521

4 August 2017

David B Donner

series ordinal

2

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PubMed ID

12217521

4 August 2017

language of work or name

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1 September 2002

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4 August 2017

6

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Trends in Biochemical Sciences

inferred from page(s)

published in

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4 August 2017

27

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4 August 2017

462-467

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4 August 2017

9

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Programmed cell death in animal development

4 August 2017

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Signalling through the lipid products of phosphoinositide-3-OH kinase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Phosphorylation of HDM2 by Akt.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

p53, the cellular gatekeeper for growth and division

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

PTEN and myotubularin: novel phosphoinositide phosphatases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

The Rb/E2F pathway: expanding roles and emerging paradigms

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

p53 mutations in human cancers

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Regulation of p53 stability

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

Regulation of PTEN transcription by p53

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902166-7

7 January 2021

10.1016/S0968-0004(02)02166-7

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12217521