New insights into fragile X syndrome: from molecules to neurobehaviors (Q28182730)

Europe PubMed Central

title

New insights into fragile X syndrome: from molecules to neurobehaviors (English)

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main subject

Fmr1 Dmel_CG6203

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Trends in Biochemical Sciences

GOA release 2020-03-11

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Peng Jin

1

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Stephen T Warren

series ordinal

2

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language of work or name

English

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publication date

March 2003

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published in

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volume

28

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issue

3

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page(s)

152-8

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cites work

Human and murine FMR-1: alternative splicing and translational initiation downstream of the CGG-repeat

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The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

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7 January 2021

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

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Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein

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7 January 2021

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain

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7 January 2021

FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding

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The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

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Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

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Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

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Analysis of neocortex in three males with the fragile X syndrome

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Abnormal development of dendritic spines in FMR1 knock-out mice

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Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex

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7 January 2021

Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle

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7 January 2021

Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor

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Pur alpha protein implicated in dendritic RNA transport interacts with ribosomes in neuronal cytoplasm

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The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport.

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Transport of fragile X mental retardation protein via granules in neurites of PC12 cells

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A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein

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A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P

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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

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Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

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The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif

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Evidence that fragile X mental retardation protein is a negative regulator of translation

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The fragile X mental retardation protein inhibits translation via interacting with mRNA

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7 January 2021

Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression

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Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

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Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties

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A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

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Post-transcriptional gene silencing by double-stranded RNA

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Non–coding RNA genes and the modern RNA world

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Stealth regulation: biological circuits with small RNA switches

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Control of developmental timing by micrornas and their targets

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Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest

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A role for the Drosophila fragile X-related gene in circadian output

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Audiogenic seizures susceptibility in transgenic mice with fragile X syndrome.

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Fragile X mice develop sensory hyperreactivity to auditory stimuli

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Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome

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Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function

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Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice.

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Fmr1 knockout mouse has a distinctive strain-specific learning impairment

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(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features

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Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation

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Dendritic Spine "Dysgenesis" and Mental Retardation

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Synaptic regulation of protein synthesis and the fragile X protein

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Synaptic synthesis of the Fragile X protein: possible involvement in synapse maturation and elimination

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Altered synaptic plasticity in a mouse model of fragile X mental retardation

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Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

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Long-term potentiation in the hippocampus of fragile X knockout mice

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7 January 2021

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12633995

1 reference

Consolidated OpenCitations Corpus – April 2017