Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment (Q28243433)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15809304%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

title

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment (English)

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10 January 2020

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4

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10 January 2020

Sandrine Humbert

6

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10 January 2020

author name string

Hélène Rangone

1

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10 January 2020

Raúl Pardo

2

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10 January 2020

Emilie Colin

3

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10 January 2020

Frédéric Saudou

5

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10 January 2020

language of work or name

English

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publication date

4 April 2005

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Journal of Biological Chemistry

10 January 2020

number of pages

8

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based on heuristic

inferred from page(s)

published in

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10 January 2020

volume

280

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10 January 2020

issue

23

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page(s)

22021-22028

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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

10 January 2020

cites work

1 reference

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Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

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Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

21 January 2018

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

1 reference

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Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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Arfaptin 2 regulates the aggregation of mutant huntingtin protein

21 January 2018

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The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

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The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization

21 January 2018

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Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

21 January 2018

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Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

21 January 2018

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Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

21 January 2018

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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

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Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

21 January 2018

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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

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Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

21 January 2018

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A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

21 January 2018

1 reference

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Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1

21 January 2018

1 reference

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Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

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Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M407528200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15809304%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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