PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes (Q28244126)

https://scigraph.springernature.com/pub.10.1007/s00125-006-0268-6

Europe PubMed Central

title

PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes (English)

0 references

1 reference

0 references

S Soyal

1

0 references

F Krempler

series ordinal

2

0 references

H Oberkofler

series ordinal

3

0 references

W Patsch

series ordinal

4

0 references

language of work or name

English

0 references

publication date

July 2006

0 references

published in

Diabetologia

0 references

volume

49

0 references

page(s)

1477-88

0 references

issue

7

0 references

exact match

0 references

cites work

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with hypertension in middle-aged men.

1 reference

12 December 2020

Activation of PPARgamma coactivator-1 through transcription factor docking

1 reference

12 December 2020

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women

1 reference

12 December 2020

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

1 reference

12 December 2020

Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

1 reference

12 December 2020

Free fatty acids increase PGC-1alpha expression in isolated rat islets.

1 reference

12 December 2020

Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha

1 reference

12 December 2020

Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor

1 reference

12 December 2020

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

1 reference

12 December 2020

Coordinate regulation of transcription and splicing by steroid receptor coregulators

1 reference

12 December 2020

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

12 December 2020

A Genome-Wide Scan for Abdominal Fat Assessed by Computed Tomography in the Quebec Family Study

1 reference

12 December 2020

1 reference

12 December 2020

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

1 reference

12 December 2020

Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

1 reference

12 December 2020

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1 reference

12 December 2020

Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population.

1 reference

12 December 2020

Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice.

1 reference

12 December 2020

Acquirement of brown fat cell features by human white adipocytes

1 reference

12 December 2020

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

1 reference

12 December 2020

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

1 reference

12 December 2020

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone

1 reference

12 December 2020

Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)

1 reference

12 December 2020

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle.

1 reference

12 December 2020

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes

1 reference

12 December 2020

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

1 reference

12 December 2020

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

1 reference

12 December 2020

Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40

1 reference

12 December 2020

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

1 reference

12 December 2020

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

1 reference

12 December 2020

The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations

1 reference

12 December 2020

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

1 reference

12 December 2020

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

1 reference

12 December 2020

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

1 reference

12 December 2020

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

1 reference

12 December 2020

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

1 reference

12 December 2020

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes

1 reference

12 December 2020

DEAD-box proteins: the driving forces behind RNA metabolism

1 reference

12 December 2020

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

12 December 2020

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

1 reference

12 December 2020

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

12 December 2020

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

12 December 2020

Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle

1 reference

12 December 2020

Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha

1 reference

12 December 2020

Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p.

1 reference

12 December 2020

Combinatorial control of gene expression by nuclear receptors and coregulators

1 reference

12 December 2020

Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes

1 reference

12 December 2020

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

1 reference

12 December 2020

1 reference

12 December 2020

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle

1 reference

12 December 2020

Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5

1 reference

12 December 2020

Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans

1 reference

12 December 2020

Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle

1 reference

12 December 2020

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

1 reference

12 December 2020

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis

1 reference

12 December 2020

A major predisposition locus for severe obesity, at 4p15-p14

1 reference

12 December 2020

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

1 reference

12 December 2020

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

1 reference

12 December 2020

Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity

1 reference

12 December 2020

Genetic factors in type 2 diabetes: the end of the beginning?

1 reference

12 December 2020

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

1 reference

12 December 2020

PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max.

1 reference

12 December 2020

Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1

1 reference

12 December 2020

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

12 December 2020

An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians

1 reference

12 December 2020

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression

1 reference

12 December 2020

Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1

1 reference

12 December 2020

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

1 reference

12 December 2020

Mammalian hibernation. Transcriptional and translational controls.

1 reference

12 December 2020

PGC-1 functions as a transcriptional coactivator for the retinoid X receptors

1 reference

12 December 2020

A unified theory of gene expression

1 reference

12 December 2020

Integrating mRNA processing with transcription

1 reference

12 December 2020

D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

1 reference

12 December 2020

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

1 reference

12 December 2020

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1

1 reference

12 December 2020

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial

1 reference

12 December 2020

Brown adipose tissue thermogenesis: interdisciplinary studies

1 reference

12 December 2020

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha

1 reference

12 December 2020

Overweight in childhood and adolescence

1 reference

12 December 2020

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.

1 reference

12 December 2020

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

1 reference

12 December 2020

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes

1 reference

12 December 2020

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

1 reference

12 December 2020

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

1 reference

12 December 2020

Lifetime Risk for Diabetes Mellitus in the United States

1 reference

12 December 2020

Increasing the complexity of coactivation in nuclear receptor signaling

1 reference

12 December 2020

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

12 December 2020

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

1 reference

12 December 2020

Regulation of mitochondrial biogenesis in skeletal muscle by CaMK

1 reference

12 December 2020

The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)

1 reference

12 December 2020

1 reference

12 December 2020

PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

1 reference

12 December 2020

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

1 reference

12 December 2020

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

12 December 2020

Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).

1 reference

12 December 2020

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

1 reference

12 December 2020

Protein displacement by DExH/D "RNA helicases" without duplex unwinding

1 reference

12 December 2020

Regulated transport of the glucose transporter GLUT4

1 reference

12 December 2020

The International HapMap Project

1 reference

12 December 2020

Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly

1 reference

12 December 2020

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

1 reference

12 December 2020

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

1 reference

12 December 2020

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

1 reference

12 December 2020

Mitochondrial dysfunction and type 2 diabetes

1 reference

12 December 2020

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

1 reference

12 December 2020