Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation (Q28250296)

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Kazuhiko Hanashiro

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Song-Hee Kim

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Shuji Hanai

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A Hamid Boulares

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Masanao Miwa

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Kenji Fukasawa

Mdm2 promotes the rapid degradation of p53

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language of work or name

English

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publication date

October 2007

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published in

Nature Cell Biology

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volume

9

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page(s)

1175-83

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issue

10

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cites work

1 reference

Regulation of p53 stability by Mdm2

20 April 2017

1 reference

Divorcing ARF and p53: an unsettled case

20 April 2017

1 reference

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

20 April 2017

1 reference

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

20 April 2017

1 reference

Activation of the p53 tumor suppressor protein

20 April 2017

1 reference

The S phase checkpoint: when the crowd meets at the fork

21 January 2018

1 reference

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

21 January 2018

1 reference

Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

21 January 2018

1 reference

ADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification

21 January 2018

1 reference

Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function

21 January 2018

1 reference

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

21 January 2018

1 reference

PARP-1 modifies the effectiveness of p53-mediated DNA damage response.

21 January 2018

1 reference

Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation

21 January 2018

1 reference

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

21 January 2018

1 reference

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

1 reference

C-terminal ubiquitination of p53 contributes to nuclear export

21 January 2018

1 reference

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

1 reference

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

21 January 2018

1 reference

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

1 reference

Control of p53 nuclear accumulation in stressed cells

21 January 2018

1 reference

Activation of p53 by roscovitine-mediated suppression of MDM2 expression

21 January 2018

1 reference

Transcription-independent pro-apoptotic functions of p53.

21 January 2018

1 reference

21 January 2018

PARP goes transcription

1 reference

Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Central and carboxy‐terminal regions of human p53 protein are essential for interaction and complex formation with PARP‐1

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression

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