Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis (Q28254513)

12

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Steven P. Gygi

11

object named as

Steven P Gygi

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author name string

Max R Banko

1

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Jasmina J Allen

2

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Bethany E Schaffer

3

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Erik W Wilker

4

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Peiling Tsou

5

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Jamie L White

6

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Beatrice Wang

8

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Sara R Kim

9

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Kei Sakamoto

10

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Michael B Yaffe

13

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Kevan M Shokat

14

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Anne Brunet

AMPK phosphorylation of raptor mediates a metabolic checkpoint

15

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language of work or name

English

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publication date

23 December 2011

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published in

Molecular Cell

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volume

44

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issue

6

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page(s)

878-92

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cites work

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Polo-like kinase controls vertebrate spindle elongation and cytokinesis

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Role of AMP-activated protein kinase in mechanism of metformin action

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Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

20 March 2017

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20 March 2017

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20 March 2017

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Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK)

20 March 2017

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

7 April 2017

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

7 April 2017

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The specificities of small molecule inhibitors of the TGFß and BMP pathways

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A fluorescent reporter of AMPK activity and cellular energy stress

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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

29 September 2017

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AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor

29 September 2017

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The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis.

29 September 2017

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AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development

29 September 2017

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Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.

29 September 2017

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Myosin phosphatase target subunit: Many roles in cell function

29 September 2017

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A novel regulatory mechanism of myosin light chain phosphorylation via binding of 14-3-3 to myosin phosphatase

29 September 2017

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Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

29 September 2017

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

29 September 2017

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

29 September 2017

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Energy-dependent regulation of cell structure by AMP-activated protein kinase

29 September 2017

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A semisynthetic epitope for kinase substrates.

29 September 2017

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

29 September 2017

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Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

29 September 2017

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Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

29 September 2017

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Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

29 September 2017

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Chemical genetic approaches for the elucidation of signaling pathways

29 September 2017

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Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases

29 September 2017

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Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.

29 September 2017

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Effects of the regulatory light chain phosphorylation of myosin II on mitosis and cytokinesis of mammalian cells

29 September 2017

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AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

29 September 2017

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Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase

29 September 2017

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Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus.

29 September 2017

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Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

2 June 2018

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Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination

2 June 2018

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

2 June 2018

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

2 June 2018

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Bio-orthogonal affinity purification of direct kinase substrates

2 June 2018

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

2 June 2018

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Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis

2 June 2018

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Mitotic kinase dynamics of the active form of AMPK (phospho-AMPKalphaThr172) in human cancer cells.

27 November 2018

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Genome-wide survey of protein kinases required for cell cycle progression.

27 November 2018

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Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity

27 November 2018

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Activation of actin-activated ATPase in smooth muscle by phosphorylation of myosin light chain with protease-activated kinase I

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22137581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemical genetic analysis of the time course of signal transduction by JNK

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22137581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2011.11.005

1 reference

1 reference

1 reference

PubMed publication ID

22137581

1 reference