Anticancer and immunosuppressive properties of bacterial prodiginines (Q28258853)

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author name string

Neil R Williamson

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Tamzin Gristwood

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Suresh R Chawrai

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George P C Salmond

The biosynthesis and regulation of bacterial prodiginines

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language of work or name

English

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publication date

December 2007

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published in

Future Microbiology

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volume

2

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issue

6

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page(s)

605-18

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cites work

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Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes

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Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomy

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Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.

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Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis

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The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

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Selective immunosuppression of prodigiosin 25-C and FK506 in the murine immune system

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Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A.

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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

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Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection

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Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines

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Prodigiosin-induced apoptosis in human colon cancer cells

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Synthesis and anti-cancer activity of C-ring-functionalized prodigiosin analogues

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Synthesis, proton-affinity and anti-cancer properties of the prodigiosin-group natural products

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Antimetastatic effect of prodigiosin through inhibition of tumor invasion

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Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin

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High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation

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Two distinct pathways leading to nuclear apoptosis

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Prodigiosin induces apoptosis by acting on mitochondria in human lung cancer cells

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Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line

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Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells

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Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation in HL-60 cells

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Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB.

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In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK.

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Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin

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The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway

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Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells

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Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl- symport

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Co-transport of H+/Cl- by a synthetic prodigiosin mimic

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Synthesis and biological evaluation of nonylprodigiosin and macrocyclic prodigiosin analogues

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Synthesis, anion-binding properties, and in vitro anticancer activity of prodigiosin analogues

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Prodigiosin is a chloride carrier that can function as an anion exchanger

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Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells

21 January 2018

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Copper-nuclease efficiency correlates with cytotoxicity for the 4-methoxypyrrolic natural products

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Influence of the a-ring on the proton affinity and anticancer properties of the prodigiosins

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Influence of the a-ring on the redox and nuclease properties of the prodigiosins: importance of the bipyrrole moiety in oxidative DNA cleavage

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Studies on DNA cleavage by cytotoxic pyrrole alkaloids reveal the distinctly different behavior of roseophilin and prodigiosin derivatives

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Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage.

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DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin

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Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs

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Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue.

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Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.

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Identification of a red-pigmented bacterium producing a potent anti-tumor N-alkylated prodigiosin as Serratia marcescens

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The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

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Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.38.128

Identifiers

DOI

10.2217/17460913.2.6.605

1 reference

Consolidated OpenCitations Corpus – April 2017

3596545

3596545

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference