Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent (Q28262376)

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28 December 2019

title

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent (English)

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28 December 2019

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4

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28 December 2019

Aristotelis Astrinidis

5

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28 December 2019

author name string

Magdalena Karbowniczek

1

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28 December 2019

Timothy Cash

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28 December 2019

Mitchell Cheung

3

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28 December 2019

Elizabeth Petri Henske

6

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28 December 2019

language of work or name

English

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publication date

18 May 2004

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Journal of Biological Chemistry

28 December 2019

published in

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28 December 2019

volume

279

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28 December 2019

issue

29

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28 December 2019

page(s)

29930-29937

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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

28 December 2019

cites work

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

21 January 2018

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

21 January 2018

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gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

21 January 2018

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The TSC1 gene product, hamartin, negatively regulates cell proliferation

21 January 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

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Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members.

21 January 2018

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The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

21 January 2018

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Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

21 January 2018

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

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Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures

21 January 2018

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Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

21 January 2018

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

21 January 2018

1 reference

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402591200

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

21 January 2018

1 reference

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

1 reference

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Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts

21 January 2018

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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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21 January 2018

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Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

21 January 2018

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The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

21 January 2018

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Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

21 January 2018

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ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

21 January 2018

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MEK kinase activity is not necessary for Raf-1 function

21 January 2018

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

21 January 2018

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Endothelial apoptosis in Braf-deficient mice

21 January 2018

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Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M402591200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15150271%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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