Neurofibromatosis type 1 - a model for nervous system tumour formation? (Q28265284)

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5 January 2020

review article

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title

Neurofibromatosis type 1 - a model for nervous system tumour formation? (English)

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5 January 2020

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2

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5 January 2020

author name string

Joshua B Rubin

series ordinal

1

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5 January 2020

language of work or name

English

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publication date

1 July 2005

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5 January 2020

published in

Nature Reviews Cancer

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5 January 2020

volume

5

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5 January 2020

issue

7

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5 January 2020

page(s)

557-564

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Two genetic hits (more or less) to cancer

5 January 2020

cites work

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Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1

21 April 2017

1 reference

The neurofibromatosis type 1 gene encodes a protein related to GAP

21 April 2017

1 reference

21 April 2017

1 reference

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

21 April 2017

1 reference

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

21 April 2017

1 reference

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

21 April 2017

1 reference

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

21 April 2017

1 reference

Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration

21 April 2017

1 reference

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 April 2017

1 reference

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

21 April 2017

1 reference

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

21 April 2017

1 reference

The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts

21 April 2017

1 reference

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

21 April 2017

1 reference

Altered neural cell fates and medulloblastoma in mouse patched mutants

21 April 2017

1 reference

Identification of human brain tumour initiating cells

21 April 2017

1 reference

Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts

21 April 2017

1 reference

NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors

21 January 2018

1 reference

Malignant peripheral nerve sheath tumors in neurofibromatosis 1.

21 January 2018

1 reference

21 January 2018

Plexiform neurofibromas

1 reference

Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas

21 January 2018

1 reference

Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas

21 January 2018

1 reference

Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation

21 January 2018

1 reference

Neurofibromatosis type 1 and optic pathway gliomas: follow-up of 54 patients

21 January 2018

1 reference

Spontaneous regression of optic gliomas: thirteen cases documented by serial neuroimaging.

21 January 2018

1 reference

Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.

21 January 2018

1 reference

21 January 2018

1 reference

Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.

21 January 2018

1 reference

Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1).

21 January 2018

1 reference

Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1.

21 January 2018

1 reference

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

21 January 2018

1 reference

Developmental regulation of a neuron-specific neurofibromatosis 1 isoform.

21 January 2018

1 reference

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

21 January 2018

1 reference

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

21 January 2018

1 reference

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

21 January 2018

1 reference

Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells

21 January 2018

1 reference

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

21 January 2018

1 reference

A role for Pak protein kinases in Schwann cell transformation

21 January 2018

1 reference

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells

21 January 2018

1 reference

Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells

21 January 2018

1 reference

Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.

21 January 2018

1 reference

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

21 January 2018

1 reference

Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.

21 January 2018

1 reference

Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides

21 January 2018

1 reference

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

21 January 2018

1 reference

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

21 January 2018

1 reference

Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

21 January 2018

1 reference

Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects

21 January 2018

1 reference

Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice

21 January 2018

1 reference

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

21 January 2018

1 reference

Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1

21 January 2018

1 reference

Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors.

31 March 2020

1 reference

Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms

31 March 2020

1 reference

Intracranial gliomas in neurofibromatosis type 1.

31 March 2020

1 reference

Optic pathway gliomas in neurofibromatosis type 1: the effect of presenting symptoms on outcome.

31 March 2020

1 reference

Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

31 March 2020

1 reference

Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes

31 March 2020

1 reference

Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras

31 March 2020

1 reference

The Neurofibromatosis 1 Gene Product Neurofibromin Regulates Pituitary Adenylate Cyclase-Activating Polypeptide-Mediated Signaling in Astrocytes

31 March 2020

1 reference

Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.

31 March 2020

1 reference

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

31 March 2020

1 reference

Natural history of neurofibromatosis 1-associated optic nerve glioma in mice

31 March 2020

1 reference

Loss of neurofibromatosis-1 and p19(ARF) cooperate to induce a multiple tumor phenotype

31 March 2020

1 reference

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1653

1 reference

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Dimensions Publication ID

5 January 2020

0 references

1 reference

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