Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes (Q28271300)

18

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Ben Berkhout

20

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Jean-Philippe Julien

5

0 references

Max Crispin

Max Crispin

24

0 references

Ian Andrew Wilson

29

Ian A Wilson

0 references

David C. Montefiori

25

David C Montefiori

0 references

Andrew B Ward

30

Andrew B Ward

0 references

Rogier W Sanders

31

Rogier W Sanders

0 references

John P. Moore

28

John P Moore

0 references

Gabriel Ozorowski

2

Gabriel Ozorowski

0 references

Per Johan Klasse

26

P J Klasse

0 references

Shane Crotty

23

Shane Crotty

0 references

Celia C LaBranche

22

Celia LaBranche

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author name string

Steven W de Taeye

1

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Alba Torrents de la Peña

3

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Miklos Guttman

4

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Tom L G M van den Kerkhof

6

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Judith A Burger

7

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Laura K Pritchard

8

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Pavel Pugach

9

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Anila Yasmeen

10

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Jordan Crampton

11

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Joyce Hu

12

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Ilja Bontjer

13

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Jonathan L Torres

14

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Heather Arendt

15

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Joanne DeStefano

16

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Wayne C Koff

17

0 references

Dirk Eggink

19

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Hansi Dean

21

0 references

Kelly K Lee

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

27

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language of work or name

English

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publication date

17 December 2015

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published in

Cell

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volume

163

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page(s)

1702-15

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issue

7

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cites work

1 reference

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Cell- and Protein-Directed Glycosylation of Native Cleaved HIV-1 Envelope

20 March 2017

1 reference

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Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

20 March 2017

1 reference

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Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

20 March 2017

1 reference

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Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

20 March 2017

1 reference

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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

20 March 2017

1 reference

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Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

20 March 2017

1 reference

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

20 March 2017

1 reference

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

20 March 2017

1 reference

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Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

20 March 2017

1 reference

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Strategies of obligate intracellular parasites for evading host defences

20 March 2017

1 reference

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HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

20 March 2017

1 reference

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Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.

20 March 2017

1 reference

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Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

29 September 2017

1 reference

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Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

29 September 2017

1 reference

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HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

29 September 2017

1 reference

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Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

HIV: A stamp on the envelope

29 September 2017

1 reference

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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

CD4-induced activation in a soluble HIV-1 Env trimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

A functional interaction between gp41 and gp120 is observed for monomeric but not oligomeric, uncleaved HIV-1 Env gp140.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

HIV-1 envelope glycoprotein trimers display open quaternary conformation when bound to the gp41 membrane-proximal external-region-directed broadly neutralizing antibody Z13e1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Increased functional stability and homogeneity of viral envelope spikes through directed evolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Germinal center B cells govern their own fate via antibody feedback

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Identification of a human immunodeficiency virus type 1 envelope glycoprotein variant resistant to cold inactivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope.

29 September 2017

1 reference

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Subversion of the immune system by pathogens.

29 September 2017

1 reference

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Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

29 September 2017

1 reference

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Simulation of B cell affinity maturation explains enhanced antibody cross-reactivity induced by the polyvalent malaria vaccine AMA1.

2 June 2018

1 reference

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Guiding the immune response against influenza virus hemagglutinin toward the conserved stalk domain by hyperglycosylation of the globular head domain

2 June 2018

1 reference

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Cross‐Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732737

10.1016/J.CELL.2015.11.056

27 November 2018

Identifiers

DOI

1 reference

190535

190535

1 reference

1 reference

1 reference