Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env (Q27644383)

52

John R Mascola

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Michael Chambers

Michael Chambers

17

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Lawrence K Lee

Lawrence K Lee

39

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Jason Gorman

Jason Gorman

6

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Tongqing Zhou

Tongqing Zhou

14

0 references

Scott C Blanchard

Scott C Blanchard

48

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Cinque Soto

11

Cinque Soto

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Peter D. Kwong

53

Peter D Kwong

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Mallika Sastry

29

Mallika Sastry

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Guillaume Stewart-Jones

30

Guillaume B E Stewart-Jones

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Adrian B. McDermott

51

Adrian B McDermott

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James Arthos

46

James Arthos

0 references

Nicole Doria-Rose

19

Nicole A Doria-Rose

0 references

M Gordon Joyce

7

M Gordon Joyce

0 references

Ivelin S. Georgiev

4

Ivelin S Georgiev

0 references

Mark K. Louder

24

Mark K Louder

0 references

Paul G. Thomas

32

Paul V Thomas

0 references

Sandeep R Narpala

10

Sandeep Narpala

0 references

James M Binley

50

James M Binley

0 references

Sijy O'Dell

25

Sijy O'Dell

0 references

Priyamvada Acharya

3

Priyamvada Acharya

0 references

Yongping Yang

13

Yongping Yang

0 references

Aliaksandr Druz

20

Aliaksandr Druz

0 references

Ulrich Baxa

41

Ulrich Baxa

0 references

Madhu S Prabhakaran

28

Madhu Prabhakaran

0 references

Miklos Guttman

8

Miklos Guttman

0 references

Marie Pancera

2

Marie Pancera

0 references

Keiko Osawa

27

Keiko Osawa

0 references

Tatsiana Kirys

23

Tatsiana Kirys

0 references

Adam Harned

22

Adam Harned

0 references

Gilad Ofek

26

Gilad Ofek

0 references

Jonathan Stuckey

31

Jonathan Stuckey

0 references

Arne Schön

42

Arne Schön

0 references

Ernesto Freire

43

Ernesto Freire

0 references

Susan Zolla-Pazner

40

Susan Zolla-Pazner

0 references

Walther Mothes

49

Walther Mothes

0 references

Baoshan Zhang

35

Baoshan Zhang

0 references

Robert Bailer

16

Robert T Bailer

0 references

Gwo-Yu Chuang

18

Gwo-Yu Chuang

0 references

author name string

Young Do Kwon

1

0 references

Emma T Crooks

5

0 references

Xiaochu Ma

9

0 references

Daniel S Terry

12

0 references

Goran Ahlsen

15

0 references

Mark A Hallen

21

0 references

Tishina Tittley

33

0 references

Constance Williams

34

0 references

Hong Zhao

36

0 references

Zhou Zhou

37

0 references

Bruce R Donald

38

0 references

Kelly K Lee

45

0 references

James B Munro

Nature Structural & Molecular Biology

47

0 references

publication date

July 2015

0 references

published in

0 references

volume

22

0 references

issue

7

0 references

page(s)

522-31

0 references

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20 March 2017

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20 March 2017

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Antibody neutralization and escape by HIV-1

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7 April 2017

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

7 April 2017

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Structure of a V3-containing HIV-1 gp120 core

7 April 2017

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7 April 2017

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7 April 2017

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

7 April 2017

1 reference

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Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

7 April 2017

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7 April 2017

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

7 April 2017

2 references

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7 April 2017

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Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

1 reference

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Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties

7 April 2017

1 reference

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Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

CD4-induced activation in a soluble HIV-1 Env trimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Broadly neutralizing influenza hemagglutinin stem-specific antibody CR8020 targets residues that are prone to escape due to host selection pressure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Enzyme digests eliminate nonfunctional Env from HIV-1 particle surfaces, leaving native Env trimers intact and viral infectivity unaffected

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs

29 September 2017

1 reference

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Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis

29 September 2017

1 reference

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Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains

29 September 2017

1 reference

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Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1.

29 September 2017

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Effect of soluble CD4 on exposure of epitopes on primary, intact, native human immunodeficiency virus type 1 virions of different genetic clades

29 September 2017

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Immunization with recombinant canarypox vectors expressing membrane-anchored glycoprotein 120 followed by glycoprotein 160 boosting fails to generate antibodies that neutralize R5 primary isolates of human immunodeficiency virus type 1.

29 September 2017

1 reference

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A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure

29 September 2017

1 reference

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Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706170

Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.

29 September 2017

1 reference

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Relative resistance of primary HIV-1 isolates to neutralization by soluble CD4.

29 September 2017

1 reference

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Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity

29 September 2017

1 reference

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Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120.

2 June 2018

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Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients

2 June 2018

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Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection.

2 June 2018

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Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Topological analysis of HIV-1 glycoproteins expressed in situ on virus surfaces reveals tighter packing but greater conformational flexibility than for soluble gp120.

21 January 2018

1 reference

The cross-clade neutralizing activity of a human monoclonal antibody is determined by the GPGR V3 motif of HIV type 1

21 January 2018

1 reference

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

31 March 2020

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Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study Group

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26098315

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12 December 2020

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Identifiers

DOI

10.1038/NSMB.3051

1 reference

Dimensions Publication ID

1020579433

0 references

1 reference

1 reference

PubMed publication ID

26098315

1 reference