Structure and immune recognition of trimeric pre-fusion HIV-1 Env. (Q35142291)

6 August 2017

Structure and immune recognition of trimeric pre-fusion HIV-1 Env. (English)

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6 August 2017

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Jason Gorman

6

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Scott C Blanchard

Scott C Blanchard

24

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Tongqing Zhou

Tongqing Zhou

2

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Myron S. Cohen

19

Myron S Cohen

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6 August 2017

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John R Mascola

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Barton F Haynes

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Lynn Morris

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Walther Mothes

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Cinque Soto

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Peter D Kwong

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6 August 2017

Guillaume Stewart-Jones

11

Guillaume B E Stewart-Jones

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M Gordon Joyce

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4

Ivelin S Georgiev

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Mark K Louder

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Priyamvada Acharya

1 reference

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Yongping Yang

1 reference

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3

Aliaksandr Druz

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1

Marie Pancera

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Gilad Ofek

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Jonathan Stuckey

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Jinghe Huang

1 reference

6 August 2017

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Baoshan Zhang

1 reference

6 August 2017

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Robert T Bailer

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Gwo-Yu Chuang

1 reference

6 August 2017

Nancy Tumba

16

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6 August 2017

James B Munro

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6 August 2017

Mark Connors

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6 August 2017

language of work or name

English

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publication date

8 October 2014

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514

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455-461

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7523

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https://scigraph.springernature.com/pub.10.1038/nature13808

6 August 2017

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Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

13 July 2018

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Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

13 July 2018

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Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

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Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity

13 July 2018

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13 July 2018

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Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

13 July 2018

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Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

13 July 2018

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

13 July 2018

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Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

13 July 2018

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Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

13 July 2018

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

13 July 2018

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Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

13 July 2018

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Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

13 July 2018

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Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

13 July 2018

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Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

13 July 2018

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

13 July 2018

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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

13 July 2018

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Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

13 July 2018

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Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin

13 July 2018

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

13 July 2018

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Cross-neutralization of influenza A viruses mediated by a single antibody loop

13 July 2018

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Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer

13 July 2018

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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

13 July 2018

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13 July 2018

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13 July 2018

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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

13 July 2018

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Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

13 July 2018

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MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.

13 July 2018

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Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure

13 July 2018

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HIV type 1 Env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies

13 July 2018

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Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

13 July 2018

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Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

13 July 2018

1 reference

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Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies

13 July 2018

1 reference

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Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region

13 July 2018

1 reference

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Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

13 July 2018

1 reference

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

13 July 2018

1 reference

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Few and far between: how HIV may be evading antibody avidity

13 July 2018

1 reference

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Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions

13 July 2018

1 reference

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Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

13 July 2018

1 reference

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Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions

13 July 2018

1 reference

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Structural basis of respiratory syncytial virus neutralization by motavizumab

13 July 2018

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Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

13 July 2018

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Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

13 July 2018

1 reference

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

13 July 2018

1 reference

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Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies

13 July 2018

1 reference

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Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging

13 July 2018

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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

13 July 2018

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Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

13 July 2018

1 reference

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Role of the HIV gp120 conserved domain 1 in processing and viral entry

13 July 2018

1 reference

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Molecular architecture of native HIV-1 gp120 trimers

13 July 2018

1 reference

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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

13 July 2018

1 reference

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Role of the HIV gp120 conserved domain 5 in processing and viral entry

13 July 2018

1 reference

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Structural specificity in coiled-coil interactions.

13 July 2018

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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

13 July 2018

1 reference

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An oxygen scavenging system for improvement of dye stability in single-molecule fluorescence experiments

13 July 2018

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Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

13 July 2018

1 reference

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GLYCAM06: a generalizable biomolecular force field. Carbohydrates

13 July 2018

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Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases

13 July 2018

1 reference

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

13 July 2018

1 reference

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Structural studies of human HIV-1 V3 antibodies.

13 July 2018

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Transglutaminase-catalyzed site-specific conjugation of small-molecule probes to proteins in vitro and on the surface of living cells

13 July 2018

1 reference

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Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.

13 July 2018

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Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant

13 July 2018

1 reference

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Structure of a V3-containing HIV-1 gp120 core

13 July 2018

1 reference

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A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

13 July 2018

1 reference

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Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1

13 July 2018

1 reference

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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

13 July 2018

1 reference

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Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

13 July 2018

1 reference

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Coot: model-building tools for molecular graphics

13 July 2018

1 reference

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Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

13 July 2018

1 reference

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MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

13 July 2018

1 reference

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CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor

13 July 2018

1 reference

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Recent developments in the PHENIX software for automated crystallographic structure determination

13 July 2018

1 reference

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Enhancing protein crystallization through precipitant synergy

13 July 2018

1 reference

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Role of the gp120 inner domain beta-sandwich in the interaction between the human immunodeficiency virus envelope glycoprotein subunits

13 July 2018

1 reference

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Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

The structural biology of type I viral membrane fusion

13 July 2018

1 reference

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Antibody neutralization and escape by HIV-1

13 July 2018

1 reference

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

13 July 2018

1 reference

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Concordant modulation of neutralization resistance and high infectivity of the primary human immunodeficiency virus type 1 MN strain and definition of a potential gp41 binding site in gp120.

13 July 2018

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Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1.

13 July 2018

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Evaluating conformational free energies: the colony energy and its application to the problem of loop prediction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Extending the accuracy limits of prediction for side-chain conformations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Protein design of an HIV-1 entry inhibitor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

The antigenic structure of the HIV gp120 envelope glycoprotein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Atomic structure of the ectodomain from HIV-1 gp41

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Core structure of gp41 from the HIV envelope glycoprotein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

HIV-1 membrane fusion mechanism: structural studies of the interactions between biologically-active peptides from gp41.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Structure of influenza haemagglutinin at the pH of membrane fusion

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Identification of structural motifs from protein coordinate data: secondary structure and first-level supersecondary structure

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Refinement of the influenza virus hemagglutinin by simulated annealing

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Effects of oligomerization on the epitopes of the human immunodeficiency virus type 1 envelope glycoproteins

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4348022

Processing of X-ray diffraction data collected in oscillation mode

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25296255

12 December 2020

inferred from PubMed ID database lookup

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13808

7 January 2021

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13808

7 January 2021

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13808

7 January 2021

On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13808

7 January 2021

Identifiers

DOI

10.1038/NATURE13808

1 reference

journals/nature/PanceraZDGSGHAC14

6 August 2017

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

6 August 2017

1 reference