Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells (Q28272252)

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E M Walsh

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Y Zhang

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C-Y Chen

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J Fujita

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Z-X J Xiao

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

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language of work or name

English

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publication date

3 July 2008

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published in

Oncogene

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volume

27

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issue

29

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page(s)

4034-43

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cites work

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pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Mdm2 promotes the rapid degradation of p53

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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

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The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

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RB regulates the stability and the apoptotic function of p53 via MDM2

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Critical contribution of the MDM2 acidic domain to p53 ubiquitination

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

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