Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice (Q28272272)

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11 June 2020

Timothy Wai

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11 June 2020

Francisco J Rupérez

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Coral Barbas

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Borja Ibanez

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author name string

Jaime García-Prieto

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Michael J Baker

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Paule Benit

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Thomas Langer

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11 June 2020

Pierre Rustin

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11 June 2020

language of work or name

English

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publication date

4 December 2015

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published in

Science

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11 June 2020

volume

350

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11 June 2020

issue

6265

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11 June 2020

page(s)

aad0116

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An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2

11 June 2020

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

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OPA1 requires mitofusin 1 to promote mitochondrial fusion

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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

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Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

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Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1

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SLP-2 is required for stress-induced mitochondrial hyperfusion

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The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

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Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

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Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

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MTERF3 is a negative regulator of mammalian mtDNA transcription

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ER tubules mark sites of mitochondrial division

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Mitochondrial fission, fusion, and stress

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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.

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Disruption of fusion results in mitochondrial heterogeneity and dysfunction

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The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble

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Mitochondrial fusion is essential for organelle function and cardiac homeostasis

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Mitochondrial elongation during autophagy: a stereotypical response to survive in difficult times.

21 January 2018

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OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

21 January 2018

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Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation

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Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria

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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

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Mitochondrial division and fusion in metabolism

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Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

21 January 2018

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OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.

21 January 2018

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Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

21 January 2018

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Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

21 January 2018

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Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

21 January 2018

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Loss of Yme1L perturbates mitochondrial dynamics

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OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury

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Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart

21 January 2018

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Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mitochondrial dynamics in the central regulation of metabolism

21 January 2018

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Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity

21 January 2018

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Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

21 January 2018

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Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox.

21 January 2018

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Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle

21 January 2018

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β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes.

21 January 2018

1 reference

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Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction

21 January 2018

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Standardized bioenergetic profiling of adult mouse cardiomyocytes.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAD0116

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26785494%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017