Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk (Q36025294)

11 August 2017

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk (English)

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11 August 2017

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13

Bruce M Spiegelman

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11 August 2017

12

Gerald I Shulman

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11 August 2017

9

Vamsi K Mootha

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11 August 2017

Christoph Handschin

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11 August 2017

Cheol Soo Choi

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11 August 2017

Sherry Chin

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11 August 2017

Sheene Kim

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11 August 2017

Dan Kawamori

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11 August 2017

Amarnath J Kurpad

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11 August 2017

Nicole Neubauer

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11 August 2017

Jiang Hu

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11 August 2017

Young-Bum Kim

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11 August 2017

Rohit N Kulkarni

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11 August 2017

language of work or name

English

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publication date

1 November 2007

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Journal of Clinical Investigation

11 August 2017

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11 August 2017

117

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11 August 2017

3463-3474

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11 August 2017

11

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2000810/fullTextXML

inferred from PubMed Central ID database lookup

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

2 October 2017

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

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Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

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2 October 2017

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

2 October 2017

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2 October 2017

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An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

2 October 2017

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2 October 2017

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

2 October 2017

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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

2 October 2017

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Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

2 October 2017

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2 October 2017

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

2 October 2017

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PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells

2 October 2017

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Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

11 July 2018

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Inhibition of insulin secretion from rat islets of Langerhans by interleukin-6. An effect distinct from that of interleukin-1.

11 July 2018

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Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

11 July 2018

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Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

23 September 2018

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Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000810

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000810

A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000810

Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000810

Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000810

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2000810

An improved method for isolation of mouse pancreatic islets

23 September 2018

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12 December 2020

Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro

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12 December 2020

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α

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12 December 2020

The effectiveness of intensive glycemic control for the prevention of vascular complications in diabetes mellitus

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12 December 2020

ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice

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12 December 2020

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals

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12 December 2020

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha

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12 December 2020

Identifiers

DOI

10.1172/JCI31785

1 reference

11 August 2017

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11 August 2017

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