Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes (Q33206144)

23 July 2017

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes (English)

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23 July 2017

10

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Peter Henry St George-Hyslop

23 July 2017

Nobuo Sanjo

2

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object named as

Peter St George-Hyslop

13

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Toshitaka Kawarai

7

object named as

Toshitaka Kawarai

1 reference

23 July 2017

11

Gerold Schmitt-Ulms

1 reference

23 July 2017

Hiroshi Hasegawa

1

1 reference

23 July 2017

Fusheng Chen

3

1 reference

23 July 2017

Yong-Jun Gu

4

1 reference

23 July 2017

Cortney Shier

5

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23 July 2017

Agnes Petit

6

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23 July 2017

Taiichi Katayama

8

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23 July 2017

Stephen D Schmidt

9

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23 July 2017

Paul E Fraser

12

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23 July 2017

language of work or name

English

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publication date

17 August 2004

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Journal of Biological Chemistry

23 July 2017

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23 July 2017

279

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23 July 2017

46455-46463

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23 July 2017

45

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

23 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Membrane topology of gamma-secretase component PEN-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Intracellular cycling of lysosomal enzyme receptors: cytoplasmic tails' tales

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Interaction of tyrosine-based sorting signals with clathrin-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406289200

21 January 2018

Identifiers

DOI

10.1074/JBC.M406289200

1 reference

23 July 2017

1 reference