Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells (Q28299365)

21

0 references

Johanna I Partanen

Johanna I Partanen

6

0 references

Camilla Böckelman

Camilla Böckelman

3

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Carsten Weiss

Carsten Weiss

18

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Tapio Visakorpi

Tapio Visakorpi

20

0 references

Tero Aittokallio

Tero Aittokallio

17

0 references

Caj Haglund

14

Caj Haglund

0 references

Agnieszka Szwajda

7

Agnieszka Szwajda

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author name string

Anchit Khanna

1

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Otto Kauko

2

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Anni Laine

4

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Ilona Schreck

5

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Stefanie Bormann

8

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Turker Bilgen

9

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Merja Helenius

10

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Yuba R Pokharel

11

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John Pimanda

12

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Mike R Russel

13

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Kristina A Cole

15

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Juha Klefström

16

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Ari Ristimäki

The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase

19

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language of work or name

English

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publication date

15 November 2013

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published in

Cancer Research

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volume

73

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issue

22

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page(s)

6757-69

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cites work

1 reference

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

20 March 2017

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The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

20 March 2017

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Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

20 March 2017

1 reference

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CIP2A inhibits PP2A in human malignancies

20 March 2017

1 reference

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

20 March 2017

1 reference

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CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice

20 March 2017

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

20 March 2017

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Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.

7 April 2017

1 reference

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CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.

29 September 2017

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Targeting the DNA damage response in oncology: past, present and future perspectives

29 September 2017

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An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

29 September 2017

1 reference

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The DNA damage response and cancer therapy

29 September 2017

1 reference

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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

29 September 2017

1 reference

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Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells

29 September 2017

1 reference

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A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

29 September 2017

1 reference

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Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

29 September 2017

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ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells

29 September 2017

1 reference

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RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

29 September 2017

1 reference

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SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.

29 September 2017

1 reference

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CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells

29 September 2017

1 reference

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The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

29 September 2017

1 reference

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CIP2A is associated with human breast cancer aggressivity

29 September 2017

1 reference

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MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.

29 September 2017

1 reference

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From promiscuity to precision: protein phosphatases get a makeover

29 September 2017

1 reference

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Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870284

Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo

29 September 2017

1 reference

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SV40 small T antigen and PP2A phosphatase in cell transformation

29 September 2017

1 reference

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Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization

29 September 2017

1 reference

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PP2A: unveiling a reluctant tumor suppressor

29 September 2017

1 reference

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Rules for making human tumor cells

29 September 2017

1 reference

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CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes

29 September 2017

1 reference

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Functional expression of sv40 in normal human prostatic epithelial and fibroblastic cells - differentiation pattern of nontumorigenic cell-lines.

2 June 2018

1 reference

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Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

2 June 2018

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Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation.

27 November 2018

1 reference

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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

27 November 2018

1 reference

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Regulation of CHK2 by DNA-dependent protein kinase

27 November 2018

1 reference

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