SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells. (Q34685327)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245140%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells (English)

1 reference

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20 January 2020

1 reference

2

1 reference

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20 January 2020

Nuria Ferrandiz

4

1 reference

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María Teresa Gómez Casares

20 January 2020

5

1 reference

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20 January 2020

Ignacio Pérez-Roger

11

1 reference

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20 January 2020

Javier León

12

1 reference

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20 January 2020

author name string

Gabriel Bretones

1

1 reference

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20 January 2020

Juan M Caraballo

3

1 reference

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20 January 2020

Marta Albajar

6

1 reference

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20 January 2020

Rosa Blanco

7

1 reference

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20 January 2020

Paula Ruiz

8

1 reference

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20 January 2020

Wen-Chun Hung

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245140%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

M Pilar Albero

10

1 reference

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20 January 2020

language of work or name

English

0 references

publication date

18 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245140%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

number of pages

11

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

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20 January 2020

volume

286

1 reference

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20 January 2020

issue

11

1 reference

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20 January 2020

page(s)

9815-9825

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245140%20AND%20SRC:MED&resulttype=core&format=json

Myc roles in hematopoiesis and leukemia

20 January 2020

cites work

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7 July 2018

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Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis

7 July 2018

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7 July 2018

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A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

7 July 2018

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Reflecting on 25 years with MYC.

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Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest

7 July 2018

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Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

7 July 2018

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Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits

7 July 2018

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Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

7 July 2018

1 reference

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

7 July 2018

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

7 July 2018

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Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo

7 July 2018

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Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

7 July 2018

1 reference

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Chronic myeloid leukaemia as a model of disease evolution in human cancer

7 July 2018

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

7 July 2018

1 reference

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Novel c-MYC target genes mediate differential effects on cell proliferation and migration

7 July 2018

1 reference

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Global mapping of c-Myc binding sites and target gene networks in human B cells

7 July 2018

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The c-Myc target gene network

7 July 2018

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Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules

7 July 2018

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Ubiquitin ligases: cell-cycle control and cancer

7 July 2018

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p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells.

7 July 2018

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

7 July 2018

1 reference

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

7 July 2018

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7 July 2018

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Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels.

7 July 2018

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7 July 2018

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Myc confers androgen-independent prostate cancer cell growth

7 July 2018

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

7 July 2018

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Skp2 regulates Myc protein stability and activity

7 July 2018

1 reference

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7 July 2018

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7 July 2018

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Jak2 is involved in c-Myc induction by Bcr-Abl

7 July 2018

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Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

7 July 2018

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Contributions of Myc to tumorigenesis

7 July 2018

1 reference

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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

7 July 2018

1 reference

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Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

7 July 2018

1 reference

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Cell cycle activation by c-myc in a burkitt lymphoma model cell line.

7 July 2018

1 reference

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c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells

7 July 2018

1 reference

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Regulation of the cdk inhibitor p27 and its deregulation in cancer

7 July 2018

1 reference

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

7 July 2018

1 reference

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

7 July 2018

1 reference

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Control of cell growth by c-Myc in the absence of cell division

7 July 2018

1 reference

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

7 July 2018

1 reference

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Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

7 July 2018

1 reference

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

7 July 2018

1 reference

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MYC oncogenes and human neoplastic disease

7 July 2018

1 reference

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059036

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

7 July 2018

1 reference

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Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo

7 July 2018

1 reference

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059036

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

7 July 2018

1 reference

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Differential regulation of Max and role of c-Myc during erythroid and myelomonocytic differentiation of K562 cells

7 July 2018

1 reference

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059036

Negative autoregulation of c-myc gene expression is inactivated in transformed cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059036

Negative autoregulation of c-myc transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059036

Inhibition of cell differentiation: a critical mechanism for MYC-mediated carcinogenesis?

7 July 2018

1 reference

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Analysis of genomic targets reveals complex functions of MYC.

21 January 2018

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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

21 January 2018

1 reference

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Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

21 January 2018

1 reference

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1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.165977

Transcriptional activation of Skp2 by BCR-ABL in K562 chronic myeloid leukemia cells

21 January 2018

1 reference

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Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.165977

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.165977

Skp2-mediated degradation of p27 regulates progression into mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.165977

BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245140

12 December 2020

inferred from PubMed ID database lookup

Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245140

12 December 2020

inferred from PubMed ID database lookup

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245140

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M110.165977

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245140%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21245140%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference