Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells (Q28397198)

2

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Ruochan Chen

3

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Xiaohua Niu

4

0 references

De Chen

5

0 references

Rui Kang

6

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Daolin Tang

HSPB1 as a novel regulator of ferroptotic cancer cell death

7

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language of work or name

English

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publication date

January 2016

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published in

Hepatology

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volume

63

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issue

1

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page(s)

173-84

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cites work

1 reference

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

19 March 2017

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Role of Nrf2 in oxidative stress and toxicity

19 March 2017

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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Global cancer statistics

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

19 March 2017

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Sorafenib in advanced hepatocellular carcinoma

19 March 2017

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

19 March 2017

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

19 March 2017

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Ferroptosis as a p53-mediated activity during tumour suppression

19 March 2017

1 reference

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Synchronized renal tubular cell death involves ferroptosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

29 September 2017

1 reference

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

29 September 2017

1 reference

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Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

29 September 2017

1 reference

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Regulation of ferroptotic cancer cell death by GPX4

29 September 2017

1 reference

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The role of iron and reactive oxygen species in cell death

29 September 2017

1 reference

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The emerging role of the Nrf2-Keap1 signaling pathway in cancer

29 September 2017

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Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma

29 September 2017

1 reference

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Toward clinical application of the Keap1-Nrf2 pathway

29 September 2017

1 reference

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Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

29 September 2017

1 reference

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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

NRF2 and cancer: the good, the bad and the importance of context.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Ferroptosis: an iron-dependent form of nonapoptotic cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

High-mobility group box 1 is essential for mitochondrial quality control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Iron, hemochromatosis, and hepatocellular carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4688087

Phase II study of sorafenib in patients with advanced hepatocellular carcinoma

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26403645

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26403645

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26403645