Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo (Q28482222)

2

An-Chi

Tsai

1 reference

20 October 2023

Mei-Chuan Chen

3

Mei-Chuan

Chen

1 reference

20 October 2023

Li-Hsun Chang

4

Li-Hsun

Chang

1 reference

20 October 2023

Hui-Lung Sun

5

Hui-Lung

Sun

1 reference

20 October 2023

Ya-Ling Chang

6

Ya-Ling

Chang

1 reference

20 October 2023

Chien-Chih Chen

7

Chien-Chih

Chen

1 reference

20 October 2023

Shiow-Lin Pan

9

Shiow-Lin

Creative Commons Attribution 4.0 International

Pan

1 reference

20 October 2023

language of work or name

English

0 references

publication date

2012

0 references

published in

PLOS One

0 references

volume

7

0 references

issue

8

0 references

page(s)

e42192

0 references

copyright license

start time

13 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

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Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-κB and JNK/p38 MAPK activation pathways.

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p53-Dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG.

29 September 2017

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Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.

29 September 2017

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Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53.

29 September 2017

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Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage

29 September 2017

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Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

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Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels

29 September 2017

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Regulation of p53 stability and function in HCT116 colon cancer cells

29 September 2017

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MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

29 September 2017

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

29 September 2017

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Flavonoids activate wild-type p53.

29 September 2017

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Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

29 September 2017

1 reference

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Mdm2: keeping p53 under control

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QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.

2 June 2018

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27 November 2018

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HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

27 November 2018

1 reference

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Structure of 8-(2,6-dideoxy-beta-ribo-hexopyranosyl)-5-hydroxy-2-(4- hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one sesquihydrate, aciculatin

27 November 2018

1 reference

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An overview of DNA and RNA bindings to antioxidant flavonoids

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22912688

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22912688

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0042192

1 reference

3521337

ADS bibcode

2012PLoSO...742192L

0 references

3521337

1 reference

1 reference

1 reference