An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development (Q28485395)

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English	An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development	scientific article

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scholarly article

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An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development (English)

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8

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author name string

Derek M van Pel

1

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Irene J Barrett

2

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Yoko Shimizu

3

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Babu V Sajesh

4

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Brent J Guppy

5

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Tom Pfeifer

6

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Kirk J McManus

7

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language of work or name

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publication date

2013

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9

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1

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e1003254

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copyright license

Creative Commons Attribution 4.0 International

31 January 2013

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April 2022 Public Data File from Crossref

copyright status

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Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication

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Rad52 inactivation is synthetically lethal with BRCA2 deficiency

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The genetic landscape of a cell

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19 March 2017

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

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19 March 2017

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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19 March 2017

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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19 March 2017

Global mapping of the yeast genetic interaction network

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Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

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Genetic instability in colorectal cancers

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7 April 2017

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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Synthetic lethality of cohesins with PARPs and replication fork mediators

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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

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29 September 2017

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

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Chromosomal instability confers intrinsic multidrug resistance.

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29 September 2017

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

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Functional regulation of FEN1 nuclease and its link to cancer

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DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

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DRYGIN: a database of quantitative genetic interaction networks in yeast

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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

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29 September 2017

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29 September 2017

Inactivation of hCDC4 can cause chromosomal instability

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FBXW7/hCDC4 is a general tumor suppressor in human cancer.

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Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.

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Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components

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21 January 2018

Involvement of flap endonuclease 1 in base excision DNA repair.

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21 January 2018

Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments

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21 January 2018

DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003254

21 January 2018

Synthetic Genetic Array (SGA) Analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003254

21 January 2018

Loss of CDC4/FBXW7 in gastric carcinoma.

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Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1

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12 December 2020

based on heuristic

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10.1371/JOURNAL.PGEN.1003254

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