Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication (Q24319178)

GOA release 2020-03-11

DNA replication

1 reference

GOA release 2020-03-11

3

Julia Sidorova

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author name string

Julien P Duxin

1

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Hayley R Moore

2

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Kenneth Karanja

4

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Yuchi Honaker

5

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Benjamin Dao

6

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Helen Piwnica-Worms

7

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Judith L Campbell

8

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Raymond J Monnat

9

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Sheila A Stewart

Journal of Biological Chemistry

10

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language of work or name

English

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publication date

22 June 2012

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published in

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volume

287

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issue

26

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page(s)

21980-91

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on focus list of Wikimedia project

ScienceSource

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cites work

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

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An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase

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Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

19 March 2017

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Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication

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Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

19 March 2017

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A network of multi-tasking proteins at the DNA replication fork preserves genome stability

19 March 2017

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The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

19 March 2017

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Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

19 March 2017

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Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

19 March 2017

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Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

19 March 2017

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Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication

19 March 2017

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Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth

19 March 2017

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A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

19 March 2017

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A yeast gene required for DNA replication encodes a protein with homology to DNA helicases

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ATR: an essential regulator of genome integrity

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

7 April 2017

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Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection

7 April 2017

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DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

27 September 2017

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Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

27 September 2017

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Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM

27 September 2017

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Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

27 September 2017

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The role of RPA2 phosphorylation in homologous recombination in response to replication arrest

27 September 2017

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Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates

27 September 2017

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Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway

27 September 2017

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Microfluidic-assisted analysis of replicating DNA molecules

27 September 2017

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DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression.

27 September 2017

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Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae

27 September 2017

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Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis

27 September 2017

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Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends

27 September 2017

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Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae

27 September 2017

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Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal

27 September 2017

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Flap endonuclease 1 contributes to telomere stability

27 September 2017

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Methods for synchronizing cells at specific stages of the cell cycle

27 September 2017

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Flap endonuclease disengages Dna2 helicase/nuclease from Okazaki fragment flaps

27 September 2017

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Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta

27 September 2017

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Lagging strand replication proteins in genome stability and DNA repair

27 September 2017

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Fission yeast Dna2 is required for generation of the telomeric single-strand overhang

27 September 2017

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On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

Junction ribonuclease: an activity in Okazaki fragment processing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

27 September 2017

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Damage-specific modification of PCNA.

27 September 2017

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FEN1 ensures telomere stability by facilitating replication fork re-initiation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381158

The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo

30 May 2018

1 reference

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21 January 2018

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21 January 2018

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Characterization of the Enzymatic Properties of the Yeast Dna2 Helicase/Endonuclease Suggests a New Model for Okazaki Fragment Processing

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