The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program (Q28511944)

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7 February 2020

title

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program (English)

2 references

25 January 2017

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7 February 2020

1 reference

Catenin (cadherin associated protein), beta 1

1 reference

Lymphoid enhancer binding factor 1

1 reference

Hes family bHLH transcription factor 7

1 reference

Mesogenin 1

1 reference

author

Deborah L Chapman

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750544%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Michael Kyba

10

1 reference

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7 February 2020

author name string

Rieko Ajima

4

2 references

25 January 2017

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7 February 2020

Michelina Iacovino

5

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750544%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Arica Beisaw

6

2 references

25 January 2017

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7 February 2020

Lionel Feigenbaum

7

2 references

25 January 2017

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7 February 2020

Jeong Kyo Yoon

9

2 references

25 January 2017

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7 February 2020

Ravindra B Chalamalasetty

1

1 reference

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7 February 2020

William C Dunty

2

1 reference

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7 February 2020

Kristin K Biris

3

1 reference

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7 February 2020

Terry P Yamaguchi

11

1 reference

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7 February 2020

language of work or name

English

0 references

publication date

12 July 2011

2 references

25 January 2017

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7 February 2020

published in

Nature Communications

2 references

25 January 2017

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7 February 2020

volume

2

2 references

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7 February 2020

page(s)

390

2 references

25 January 2017

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Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites

7 February 2020

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The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity

19 March 2017

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LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

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Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

19 March 2017

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Wnt3a plays a major role in the segmentation clock controlling somitogenesis

19 March 2017

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Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

19 March 2017

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

19 March 2017

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

19 March 2017

1 reference

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Dynamic expression and essential functions of Hes7 in somite segmentation

19 March 2017

1 reference

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Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm

19 March 2017

1 reference

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The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm

19 March 2017

1 reference

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Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

19 March 2017

1 reference

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Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6

19 March 2017

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Wnt-3a regulates somite and tailbud formation in the mouse embryo

19 March 2017

1 reference

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Structure and function of helix-loop-helix proteins

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

7 April 2017

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Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.

7 April 2017

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Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis

29 September 2017

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A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors

29 September 2017

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Control of segment number in vertebrate embryos

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Segmental patterning of the vertebrate embryonic axis

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation.

2 June 2018

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lunatic fringe is an essential mediator of somite segmentation and patterning.

2 June 2018

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2 June 2018

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A complex oscillating network of signaling genes underlies the mouse segmentation clock.

2 June 2018

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Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation.

21 January 2018

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Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.

21 January 2018

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FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis.

21 January 2018

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FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation.

21 January 2018

1 reference

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Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis.

21 January 2018

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The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite.

21 January 2018

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Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling.

21 January 2018

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Distinct regulatory elements direct delta1 expression in the nervous system and paraxial mesoderm of transgenic mice.

21 January 2018

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Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock.

21 January 2018

1 reference

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Cdx4 is a direct target of the canonical Wnt pathway.

21 January 2018

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FusionDB: a database for in-depth analysis of prokaryotic gene fusion events

21 January 2018

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Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse

21 January 2018

1 reference

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A clock and wavefront model for control of the number of repeated structures during animal morphogenesis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21750544

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21750544

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A β-catenin gradient links the clock and wavefront systems in mouse embryo segmentation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21750544

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS1381

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750544%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 February 2020

ADS bibcode

2011NatCo...2..390C

0 references

1024600547

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750544%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750544%20AND%20SRC:MED&resulttype=core&format=json