Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection (Q28552598)

2

object named as

Kimberly Cramer-Morales

Kimberly

Cramer-Morales

1 reference

10 November 2023

8

Tomasz Skorski

Tomasz

Skorski

1 reference

10 November 2023

Katherine Sullivan

1

Katherine

Sullivan

1 reference

10 November 2023

Daniel L McElroy

3

Daniel L

McElroy

1 reference

10 November 2023

David A Ostrov

4

David A

Ostrov

1 reference

10 November 2023

Kimberly Haas

5

Kimberly

Haas

1 reference

10 November 2023

Wayne Childers

6

Wayne

Childers

1 reference

10 November 2023

Robert Hromas

7

Robert

Creative Commons Attribution 4.0 International

Hromas

1 reference

10 November 2023

language of work or name

English

0 references

publication date

2016

0 references

published in

PLOS One

0 references

volume

11

0 references

issue

1

0 references

page(s)

e0147230

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copyright license

start time

19 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease

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Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

19 March 2017

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

19 March 2017

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Rad52 inactivation is synthetically lethal with BRCA2 deficiency

19 March 2017

1 reference

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Automated docking screens: a feasibility study

19 March 2017

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Genetic steps of mammalian homologous repair with distinct mutagenic consequences

19 March 2017

1 reference

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Structure of the single-strand annealing domain of human RAD52 protein

19 March 2017

1 reference

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Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form

19 March 2017

1 reference

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Genetic analysis of BRCA1 function in a defined tumor cell line

19 March 2017

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DNA repair pathways as targets for cancer therapy

19 March 2017

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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

7 April 2017

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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

7 April 2017

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Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors

7 April 2017

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Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

29 September 2017

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Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation

29 September 2017

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Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

29 September 2017

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Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response

29 September 2017

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Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

29 September 2017

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Lipophilicity in drug discovery

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RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

29 September 2017

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Antileukemic effects of AMPK activators on BCR-ABL-expressing cells

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Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

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Identification of a second DNA binding site in the human Rad52 protein

29 September 2017

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Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections

29 September 2017

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Peptide aptamers as guides for small-molecule drug discovery.

29 September 2017

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Double-strand breaks and translocations in cancer

29 September 2017

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I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks.

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0147230

10.1371/JOURNAL.PONE.0147230

21 January 2018

Identifiers

DOI

1 reference

3529676

ADS bibcode

2016PLoSO..1147230S

0 references

3529676

1 reference

1 reference

1 reference