Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway (Q28576523)

31 January 2017

title

Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway (English)

1 reference

31 January 2017

Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.125542

17 July 2024

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

17 July 2024

5

Brent R. Stockwell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

17 July 2024

author name string

Hemant Varma

1

1 reference

31 January 2017

Ai Yamamoto

2

1 reference

31 January 2017

Melissa R. Sarantos

3

1 reference

31 January 2017

Robert E. Hughes

4

1 reference

31 January 2017

language of work or name

English

0 references

publication date

26 November 2010

1 reference

31 January 2017

21 September 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

full work available at URL

17 July 2024

http://www.jbc.org/article/S0021925820467201/pdf

file format

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

http://intl.jbc.org/cgi/content/abstract/285/48/37445

17 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20858895/?tool=EBI

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20858895/pdf/?tool=EBI

17 July 2024

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Portable Document Format

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

https://europepmc.org/articles/PMC2988350

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

https://europepmc.org/articles/PMC2988350?pdf=render

17 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20858895

https://api.elsevier.com/content/article/PII:S0021925820467201?httpAccept=text/xml

17 July 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.125542

https://api.elsevier.com/content/article/PII:S0021925820467201?httpAccept=text/plain

17 July 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.125542

https://syndication.highwire.org/content/doi/10.1074/jbc.M110.125542

17 July 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.125542

Journal of Biological Chemistry

17 July 2024

published in

1 reference

31 January 2017

volume

285

1 reference

31 January 2017

issue

48

1 reference

31 January 2017

page(s)

37445–37457

1 reference

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

31 January 2017

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Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

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CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

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29 September 2017

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Mutant huntingtin can paradoxically protect neurons from death

29 September 2017

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29 September 2017

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29 September 2017

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Inhibitors of metabolism rescue cell death in Huntington's disease models.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

29 September 2017

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29 September 2017

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p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

29 September 2017

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Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

29 September 2017

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29 September 2017

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Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

29 September 2017

1 reference

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

29 September 2017

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The mitotic spindle: a self-made machine

29 September 2017

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Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

29 September 2017

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Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

29 September 2017

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29 September 2017

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Wild-type huntingtin protects from apoptosis upstream of caspase-3.

29 September 2017

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

29 September 2017

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Replicating Huntington's disease phenotype in experimental animals

29 September 2017

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29 September 2017

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29 September 2017

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The influence of huntingtin protein size on nuclear localization and cellular toxicity.

29 September 2017

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

29 September 2017

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29 September 2017

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Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

29 September 2017

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Taxol stabilizes microtubules in mouse fibroblast cells

29 September 2017

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29 September 2017

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Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

3 June 2018

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3 June 2018

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

21 January 2018

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Biological abnormalities of peripheral A(2A) receptors in a large representation of polyglutamine disorders and Huntington's disease stages

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

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Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

21 January 2018

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

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Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

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Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

21 January 2018

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Preparation of large quantities of synchronized mammalian cells in late G1 in the pre-DNA replicative phase of the cell cycle

27 November 2018

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https://pubmed.ncbi.nlm.nih.gov/20858895

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination

1 reference

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

25

51

5

Stähelin

1991

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.125542

17 July 2024

Identifiers

1 reference

release_nii5tpc5ibfvphfs6aufllk57a

31 January 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nii5tpc5ibfvphfs6aufllk57a

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

2988350

0 references

1 reference