Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation (Q28586404)

2

Marie-Claude Guillemin

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Hugues de Thé

15

Hugues de Thé

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Nasr Rihab

1

Valérie Lallemand-Breitenbach

Rihab Nasr

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31 January 2017

9

Valérie Lallemand-Breitenbach

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31 January 2017

11

Dominique Vitoux

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31 January 2017

Omar Ferhi

3

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31 January 2017

Hassan Soilihi

4

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31 January 2017

Laurent Peres

5

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31 January 2017

Caroline Berthier

6

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31 January 2017

Philippe Rousselot

7

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31 January 2017

Macarena Robledo-Sarmiento

8

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31 January 2017

Bernard Gourmel

10

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31 January 2017

Cécile Rochette-Egly

13

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31 January 2017

Jun Zhu

PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

14

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31 January 2017

language of work or name

English

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publication date

1 December 2008

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31 January 2017

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31 January 2017

14

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31 January 2017

12

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31 January 2017

1333–1342

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31 January 2017

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7 January 2021

Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha

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7 January 2021

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

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7 January 2021

A sumoylation site in PML/RARA is essential for leukemic transformation.

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7 January 2021

Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization

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7 January 2021

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

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7 January 2021

RXR is an essential component of the oncogenic PML/RARA complex in vivo

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7 January 2021

Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

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7 January 2021

Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

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7 January 2021

Acute promyelocytic leukemia: from highly fatal to highly curable

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7 January 2021

Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

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7 January 2021

Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice

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7 January 2021

Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

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7 January 2021

Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation

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7 January 2021

Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia

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7 January 2021

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

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7 January 2021

Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis

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7 January 2021

Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

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7 January 2021

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

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7 January 2021

Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia

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7 January 2021

Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia

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7 January 2021

All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

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7 January 2021

Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia

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7 January 2021

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

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7 January 2021

Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line

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7 January 2021

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

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7 January 2021

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

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7 January 2021

Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.

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7 January 2021

Cancer stem cells: lessons from leukemia.

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7 January 2021

Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells

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7 January 2021

Two critical hits for promyelocytic leukemia

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7 January 2021

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

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7 January 2021

Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways.

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7 January 2021

How acute promyelocytic leukaemia revived arsenic

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7 January 2021

Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia

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7 January 2021

Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors

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7 January 2021

PML targeting eradicates quiescent leukaemia-initiating cells

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7 January 2021

Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.

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7 January 2021

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

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7 January 2021

Essential role of Plzf in maintenance of spermatogonial stem cells

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7 January 2021

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha

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7 January 2021

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

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7 January 2021

Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group

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7 January 2021