The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor (Q28587209)

31 January 2017

title

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor (English)

1 reference

MAP kinase-activated protein kinase 5

31 January 2017

main subject

1 reference

GOA release 2020-03-11

3

Ingebrigt Sylte

1 reference

31 January 2017

4

Ugo Moens

1 reference

31 January 2017

1

Sergiy Kostenko

1 reference

31 January 2017

author name string

Mahmud Tareq Hassan Khan

series ordinal

2

1 reference

31 January 2017

publication date

1 January 2011

1 reference

Cellular and Molecular Life Sciences

31 January 2017

published in

1 reference

31 January 2017

volume

68

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31 January 2017

issue

2

1 reference

31 January 2017

page(s)

289–301

1 reference

High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand

31 January 2017

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1 reference

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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Signal transduction by the JNK group of MAP kinases

17 March 2017

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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PRAK, a novel protein kinase regulated by the p38 MAP kinase

17 March 2017

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The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

17 March 2017

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MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

17 March 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

17 March 2017

1 reference

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A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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9 May 2017

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Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

29 September 2017

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The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.

29 September 2017

1 reference

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Targeting innate immunity protein kinase signalling in inflammation

29 September 2017

1 reference

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Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

29 September 2017

1 reference

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PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

29 September 2017

1 reference

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29 September 2017

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MK2 and MK3--a pair of isoenzymes?

29 September 2017

1 reference

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29 September 2017

1 reference

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The RSK factors of activating the Ras/MAPK signaling cascade

29 September 2017

1 reference

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Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity

29 September 2017

1 reference

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MAPKs: function, regulation, role in cancer and therapeutic targeting

29 September 2017

1 reference

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Regulatory mechanisms and functions of MAP kinase signaling pathways.

29 September 2017

1 reference

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Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives

29 September 2017

1 reference

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MAPKAP kinases - MKs - two's company, three's a crowd

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Role of mitogen-activated protein (MAP) kinases in cardiovascular diseases

29 September 2017

1 reference

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Identification of inhibitors for a virally encoded protein kinase by 2 different screening systems: in vitro kinase assay and in-cell activity assay

29 September 2017

1 reference

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29 September 2017

1 reference

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Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention

29 September 2017

1 reference

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The p38 signal transduction pathway: activation and function

29 September 2017

1 reference

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Organization and regulation of mitogen-activated protein kinase signaling pathways

29 September 2017

1 reference

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MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Knowledge-based potentials for protein folding: what can we learn from known protein structures?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Are proteins ideal mixtures of amino acids? Analysis of energy parameter sets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Regulation and function of the JNK subgroup of MAP kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Multiple model approach--dealing with alignment ambiguities in protein modeling.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Diterpenoid Alkaloids from Delphinium majus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3016492

New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20640477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Does MK5 reconcile classical and atypical MAP kinases?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20640477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20640477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00018-010-0452-1

1 reference

31 January 2017

0 references

1 reference