Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease (Q28588308)

31 January 2017

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25 February 2020

title

Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease (English)

2 references

31 January 2017

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25 February 2020

1 reference

ATP-binding cassette, sub-family A (ABC1), member 7

1 reference

GOA release 2020-03-11

author

Hongyun Li

2

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25 February 2020

Tim Karl

8

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25 February 2020

author name string

Kalani Ruberu

3

2 references

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25 February 2020

Sharon Chan

4

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31 January 2017

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25 February 2020

Jac Kee Low

6

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25 February 2020

David Cheng

7

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25 February 2020

Brett Garner

9

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25 February 2020

Woojin S Kim

1

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David A Elliott

5

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25 February 2020

language of work or name

English

0 references

publication date

1 March 2013

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25 February 2020

published in

Journal of Neuroscience

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volume

33

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issue

10

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page(s)

4387-4394

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describes a project that uses

25 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)

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Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid

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Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

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12 December 2020

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

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12 December 2020

Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

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Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.

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Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.

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The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

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12 December 2020

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

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12 December 2020

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

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12 December 2020

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

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Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells.

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ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis

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ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

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Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

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Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

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12 December 2020

Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism

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Macrophage apolipoprotein-E knockdown modulates caspase-3 activation without altering sensitivity to apoptosis

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

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ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

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ApoE promotes the proteolytic degradation of Abeta

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Isoform-specific proteolysis of apolipoprotein-E in the brain

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Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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Microglia in neurodegenerative disease

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The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

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Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons

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Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

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12 December 2020

Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).

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12 December 2020

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

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12 December 2020

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

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12 December 2020

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis

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Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

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12 December 2020

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice

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12 December 2020

Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice

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12 December 2020

Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases

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12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

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12 December 2020

10.1523/JNEUROSCI.4165-12.2013

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

1578683

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1578683

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25 February 2020

2 references

Consolidated OpenCitations Corpus – April 2017

1578683