Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies (Q28590387)

Sestrin 1

1 reference

Phosphatidylinositol 3-kinase 92E Dmel_CG4141

1 reference

Insulin-like receptor Dmel_CG18402

1 reference

Sestrin Dmel_CG11299

1 reference

Ras homolog enriched in brain Dmel_CG1081

1 reference

Target of rapamycin Dmel_CG5092

1 reference

Tsc1 Dmel_CG6147

1 reference

11

Michael Karin

1 reference

31 January 2017

Jun Hee Lee

1

1 reference

31 January 2017

Andrei V. Budanov

2

1 reference

31 January 2017

Eek Joong Park

3

1 reference

31 January 2017

Ryan Birse

4

1 reference

31 January 2017

Teddy E. Kim

5

1 reference

31 January 2017

Guy A. Perkins

6

1 reference

31 January 2017

Karen Ocorr

7

1 reference

31 January 2017

Mark H. Ellisman

8

1 reference

31 January 2017

Rolf Bodmer

9

1 reference

31 January 2017

Ethan Bier

Caloric restriction delays disease onset and mortality in rhesus monkeys

10

1 reference

31 January 2017

language of work or name

English

0 references

publication date

5 March 2010

1 reference

31 January 2017

1 reference

31 January 2017

327

1 reference

31 January 2017

1223–1228

1 reference

31 January 2017

5970

1 reference

31 January 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

TOR signaling in growth and metabolism

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Upstream and downstream of mTOR

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Autophagy regulates lipid metabolism

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

FOXO transcription factors at the interface between longevity and tumor suppression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

How to live long and prosper: autophagy, mitochondria, and aging

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

TOR pathway: linking nutrient sensing to life span

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Insulin regulation of heart function in aging fruit flies

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866632

Electron Microscope Studies on Aging Drosophila melanogaster III. Flight Muscle

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20203043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20203043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1182228

1 reference

3271589

ADS bibcode

2010Sci...327.1223L

0 references

3271589

1 reference

1 reference

1 reference