Target of rapamycin Dmel_CG5092 (Q51235924)

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Protein found in Drosophila melanogaster

CG5092 gene product from transcript CG5092-RB
target of rapamycin kinase
Tor-PA
CG5092-PB
Tor-PB
target of rapamycin complex 1
target of rapamycin
CG5092-PA
Tor
Target-of-rapamycin
mTOR

Language	Label	Description	Also known as
English	Target of rapamycin Dmel_CG5092	Protein found in Drosophila melanogaster	CG5092 gene product from transcript CG5092-RB target of rapamycin kinase Tor-PA CG5092-PB Tor-PB target of rapamycin complex 1 target of rapamycin CG5092-PA Tor Target-of-rapamycin mTOR

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

28 February 2018

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

FKBP12-rapamycin binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Tetratricopeptide-like helical domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Serine/threonine-protein kinase TOR

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Armadillo-like helical

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase, FAT family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FKBP12-rapamycin binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase family

1 reference

based on heuristic

inferred from protein domain or family

FATC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF3385, target of rapamycin protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

protein kinase activity

determination method

1 reference

24 April 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

determination method

protein serine/threonine kinase activity

determination method

protein binding

determination method

1 reference

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

kinase activity

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

protein self-association

determination method

1 reference

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

protein-containing complex binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

protein serine/threonine kinase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

chromatin DNA binding

determination method

1 reference

8 April 2019

RNA polymerase III limits longevity downstream of TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

1 reference

8 April 2019

A genome-wide resource for the analysis of protein localisation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

biological process

regulation of cell growth

determination method

1 reference

8 April 2019

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of protein phosphorylation

determination method

1 reference

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

1 reference

8 April 2019

Distinct requirements of Autophagy-related genes in programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

terminal branching, open tracheal system

determination method

1 reference

8 April 2019

Compensatory branching morphogenesis of stalk cells in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

myoblast fusion

determination method

1 reference

8 April 2019

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

somatic muscle development

determination method

1 reference

8 April 2019

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

response to nutrient

determination method

1 reference

8 April 2019

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

determination of adult lifespan

determination method

1 reference

8 April 2019

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

gonad development

determination method

1 reference

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

negative regulation of macroautophagy

determination method

1 reference

24 April 2018

Role and regulation of starvation-induced autophagy in the Drosophila fat body

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

determination method

cellular response to nutrient

determination method

1 reference

8 April 2019

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

endocytic recycling

determination method

1 reference

8 April 2019

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

larval midgut cell programmed cell death

determination method

1 reference

8 April 2019

Distinct requirements of Autophagy-related genes in programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

multicellular organism growth

determination method

1 reference

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

TORC1 signaling

determination method

1 reference

24 April 2018

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of multicellular organism growth

determination method

1 reference

8 April 2019

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

apical protein localization

determination method

1 reference

8 April 2019

Compensatory branching morphogenesis of stalk cells in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of cell size

determination method

6 references

8 April 2019

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

PDGF/VEGF signaling controls cell size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of synaptic assembly at neuromuscular junction

determination method

1 reference

8 April 2019

Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of insulin receptor signaling pathway

determination method

1 reference

8 April 2019

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

germarium-derived cystoblast division

determination method

1 reference

8 April 2019

TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

dendrite morphogenesis

determination method

1 reference

8 April 2019

The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of protein kinase B signaling

determination method

3 references

8 April 2019

Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

8 April 2019

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of ribosome biogenesis

determination method

1 reference

8 April 2019

Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

negative regulation of proteasomal protein catabolic process

determination method

1 reference

8 April 2019

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of axon guidance

determination method

1 reference

8 April 2019

Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of cell cycle G1/S phase transition

determination method

1 reference

8 April 2019

Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

regulation of terminal button organization

determination method

1 reference

8 April 2019

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

regulation of response to drug

determination method

1 reference

8 April 2019

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

negative regulation of autophagy

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

lamellocyte differentiation

determination method

1 reference

8 April 2019

Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

positive regulation of transcription by RNA polymerase III

determination method

1 reference

8 April 2019

RNA polymerase III limits longevity downstream of TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

germline cell cycle switching, mitotic to meiotic cell cycle

determination method

1 reference

8 April 2019

TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination method

PIK-related kinase, FAT

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

FKBP12-rapamycin binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Domain of unknown function DUF3385, target of rapamycin protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Tetratricopeptide repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

PIK-related kinase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

tetratricopeptide repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VK45

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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