Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control (Q35057313)

6 August 2017

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title

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control (English)

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6 August 2017

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Sean Oldham

1

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PubMed ID

12559758

6 August 2017

Ernst Hafen

series ordinal

2

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PubMed ID

12559758

6 August 2017

language of work or name

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1 February 2003

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6 August 2017

Trends in Cell Biology

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6 August 2017

13

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6 August 2017

79-85

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6 August 2017

2

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Insulin signalling and the regulation of glucose and lipid metabolism

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Distinct and overlapping functions of insulin and IGF-I receptors

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Signal transduction by receptors with tyrosine kinase activity

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

PI 3-kinase, mTOR, protein synthesis and cancer

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

IGF-I receptor signalling in transformation and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The multistep nature of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Genetic control of cell size

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Characterization of Drosophila insulin receptor substrate

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

PI3-kinase inhibition: a target for drug development?

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Growth regulation by oncogenes--new insights from model organisms

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Identification of TOR signaling complexes: more TORC for the cell growth engine

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Amino acid regulation of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Amino-acid-dependent signal transduction

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Ribosomal S6 kinase signaling and the control of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Synthesis of the translational apparatus is regulated at the translational level

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The minute genes in Drosophila and their molecular functions.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Drosophila S6 kinase: a regulator of cell size.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Oncogenic kinase signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Interplay between insulin and nutrients in the regulation of translation factors

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2900042-9

7 January 2021

10.1016/S0962-8924(02)00042-9

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12559758