Tsc1 Dmel_CG6147 (Q29818026)

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Protein found in Drosophila melanogaster

TTuberous sclerosis complex 1
hamartin
jolly green giant
Tsc1
CG6147 gene product from transcript CG6147-RA
rocky
tuberous sclerosis complex protein 1
tuberous sclerosis 1
CG6147-PA
Tsc1-PA
tuberous sclerosis complex 1

Language	Label	Description	Also known as
English	Tsc1 Dmel_CG6147	Protein found in Drosophila melanogaster	TTuberous sclerosis complex 1 hamartin jolly green giant Tsc1 CG6147 gene product from transcript CG6147-RA rocky tuberous sclerosis complex protein 1 tuberous sclerosis 1 CG6147-PA Tsc1-PA tuberous sclerosis complex 1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VCC9

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

1 reference

1 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

TSC1-TSC2 complex

determination method

1 reference

1 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

biological process

regulation of cell growth

determination method

1 reference

1 January 2018

Control of growth and organ size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

signal transduction

determination method

1 reference

1 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

open tracheal system development

determination method

1 reference

1 January 2018

A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

response to nutrient

determination method

1 reference

1 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

negative regulation of cell population proliferation

determination method

1 reference

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

insulin receptor signaling pathway

determination method

1 reference

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

determination of adult lifespan

determination method

1 reference

1 January 2018

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

positive regulation of autophagy

determination method

1 reference

1 January 2018

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

negative regulation of cell growth

determination method

3 references

1 January 2018

Rheb fills a GAP between TSC and TOR.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of actin cytoskeleton organization

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

larval midgut histolysis

determination method

1 reference

1 January 2018

Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

enteroendocrine cell differentiation

determination method

1 reference

1 January 2018

TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

intestinal stem cell homeostasis

determination method

1 reference

1 January 2018

TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

TORC1 signaling

determination method

1 reference

1 January 2018

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of cell population proliferation

determination method

1 reference

1 January 2018

Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of phosphorylation

determination method

1 reference

1 January 2018

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

cholesterol homeostasis

determination method

1 reference

1 January 2018

A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

positive regulation of GTPase activity

determination method

1 reference

1 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

negative regulation of cell size

determination method

6 references

1 January 2018

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of organ growth

determination method

1 reference

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

negative regulation of organ growth

determination method

3 references

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

negative regulation of insulin receptor signaling pathway

determination method

1 reference

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

determination method

1 reference

1 January 2018

The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of timing of cell differentiation

determination method

1 reference

1 January 2018

Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

negative regulation of developmental growth

determination method

1 reference

1 January 2018

Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

lipid homeostasis

determination method

1 reference

1 January 2018

Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

cellular response to hypoxia

determination method

1 reference

1 January 2018

An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

cellular response to chloroquine

determination method

1 reference

1 January 2018

Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

positive regulation of TORC2 signaling

determination method

1 reference

1 January 2018

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of terminal button organization

determination method

1 reference

1 January 2018

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

1 January 2018

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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