Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells (Q24303794)

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English	Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells	scientific article

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17 November 2019

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells (English)

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17 November 2019

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Donald M O'Rourke

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17 November 2019

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Gurpreet S Kapoor

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17 November 2019

Yi Zhan

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17 November 2019

Gibbes R Johnson

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1 January 2004

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17 November 2019

Molecular and Cellular Biology

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17 November 2019

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17 November 2019

823-836

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17 November 2019

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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19 March 2017

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

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The PI3K-PDK1 connection: more than just a road to PKB

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Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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IKAP is a scaffold protein of the IkappaB kinase complex

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

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Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

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Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression

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The gift of Gab.

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ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

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The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

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All signaling is local?

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Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343802

29 November 2018

A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343802

29 November 2018

Analysis of the NF-kappa B and PI 3-kinase/Akt survival pathways in nerve growth factor-dependent neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/14701753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/14701753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noonan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/14701753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/14701753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14701753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14701753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertelorism With Turner Phenotype

1 reference

https://api.crossref.org/works/10.1128%2FMCB.24.2.823-836.2004

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1128/MCB.24.2.823-836.2004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14701753%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14701753%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14701753%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

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