TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes (Q28594881)

GOA release 2020-03-11

thymocyte

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author name string

Ramireddy Bommireddy

1

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1 February 2017

Ilona Ormsby

2

1 reference

1 February 2017

Moying Yin

3

1 reference

1 February 2017

Gregory P. Boivin

4

1 reference

1 February 2017

George F. Babcock

5

1 reference

1 February 2017

Thomas Doetschman

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

6

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1 February 2017

language of work or name

English

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publication date

1 April 2003

1 reference

1 February 2017

Journal of Immunology

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1 February 2017

170

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1 February 2017

7

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1 February 2017

3645–3652

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1 February 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

17 March 2017

1 reference

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FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

Transforming growth factor-beta 1 induces antigen-specific unresponsiveness in naive T cells

17 March 2017

1 reference

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TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

17 March 2017

1 reference

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Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

17 March 2017

1 reference

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Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux

17 March 2017

1 reference

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

17 March 2017

1 reference

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How cells read TGF-beta signals

17 March 2017

1 reference

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TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II.

7 April 2017

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Requirement for transforming growth factor beta1 in controlling T cell apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

29 September 2017

1 reference

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

29 September 2017

1 reference

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Transforming growth factor-beta induces apoptosis in activated murine T cells through the activation of caspase 1-like protease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

Regulatory T cells in autoimmmunity*.

29 September 2017

1 reference

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Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

29 September 2017

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When engineered to produce latent TGF-beta1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes

29 September 2017

1 reference

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Murine models define the role of TGF-beta as a master regulator of immune cell function

29 September 2017

1 reference

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TGF-beta influences the life and death decisions of T lymphocytes

29 September 2017

1 reference

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The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases

29 September 2017

1 reference

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Cbl-b regulates the CD28 dependence of T-cell activation.

29 September 2017

1 reference

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Transforming growth factor beta1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor

29 September 2017

1 reference

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Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis

29 September 2017

1 reference

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804068

Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

29 September 2017

1 reference

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Differential requirements for survival and proliferation of CD8 naïve or memory T cells

29 September 2017

1 reference

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Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated

29 September 2017

1 reference

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Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice

29 September 2017

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Autoimmune myocarditis: a paradigm of post-infection autoimmune disease

29 September 2017

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The cell biology of transforming growth factor beta

29 September 2017

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Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering

29 September 2017

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Development of CD25(+) T cells secreting transforming growth factor-beta1 by altered peptide ligands expressed as self-antigens

29 September 2017

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Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

3 June 2018

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Induction of oral tolerance in TGF-beta 1 null mice.

3 June 2018

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FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.

3 June 2018

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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

3 June 2018

1 reference

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Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice.

3 June 2018

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FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

3 June 2018

1 reference

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FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.

3 June 2018

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Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

27 November 2018

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Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

27 November 2018

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Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.

27 November 2018

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Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells

27 November 2018

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IL-2-independent activation and proliferation in human T cells induced by CD28.

27 November 2018

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Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells.

27 November 2018

1 reference

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The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

27 November 2018

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Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.

27 November 2018

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Phorbol ester-stimulated T lymphocytes show enhanced adhesion to human endothelial cell monolayers

27 November 2018

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12 December 2020

Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta

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The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA

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Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1

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Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4,

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Regulation of CD4 and CD8 expression on mouse T cells. Active removal from the cell surface by two mechanisms

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Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity

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Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma

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Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb

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12 December 2020

A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice

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12 December 2020

TGF-beta1 is essential for the homeostasis of the dentin-pulp complex

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12 December 2020

The three isoforms of transforming growth factor-beta co-stimulate rat T cells and inhibit lymphocyte apoptosis

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12 December 2020

The function of TGF-beta-mediated innocent bystander suppression associated with physiological self-tolerance in vivo

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12 December 2020

Strain dependency of TGFbeta1 function during embryogenesis

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Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse

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12 December 2020

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

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12 December 2020

Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis

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12 December 2020

The Smad3 Protein Is Involved in TGF- Inhibition of Class II Transactivator and Class II MHC Expression

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12 December 2020

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

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12 December 2020