Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs (Q28829378)

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Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

Language	Label	Description	Also known as
English	Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs	scientific article	Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

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scholarly article

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Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs (English)

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6

object named as

Alan R Fersht

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Andreas C Joerger

7

object named as

Andreas C Joerger

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object named as

Matthias R Bauer

1

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object named as

Rainer Wilcken

4

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Frank M. Boeckler

object named as

Frank M Boeckler

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object named as

John Spencer

8

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author name string

Rhiannon N Jones

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Matthias G J Baud

3

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language of work or name

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publication date

19 August 2016

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ACS Chemical Biology

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11

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8

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2265-74

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Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

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16 March 2017

Small molecule induced reactivation of mutant p53 in cancer cells

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16 March 2017

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

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Overview of the CCP4 suite and current developments

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16 March 2017

Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments

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16 March 2017

Features and development of Coot

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16 March 2017

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16 March 2017

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16 March 2017

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994063

16 March 2017

Fluorine in pharmaceuticals: looking beyond intuition

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16 March 2017

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia

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16 March 2017

Scaling and assessment of data quality

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16 March 2017

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions

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16 March 2017

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16 March 2017

Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase

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16 March 2017

Blinded by the Light: The Growing Complexity of p53

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7 April 2017

Cancer. p53, guardian of the genome

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7 April 2017

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

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3 June 2018

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

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3 June 2018

Intermolecular Sulfur···Oxygen Interactions: Theoretical and Statistical Investigations

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3 June 2018

Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes

1 reference

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3 June 2018

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design.

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3 June 2018

Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

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3 June 2018

Intimate interactions with carbonyl groups: dipole-dipole or n→π*?

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3 June 2018

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

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3 June 2018

First-order rate-determining aggregation mechanism of p53 and its implications

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3 June 2018

Fluorine local environment: from screening to drug design

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3 June 2018

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.

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3 June 2018

Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles

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3 June 2018

The tumor suppressor p53: from structures to drug discovery

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3 June 2018

A medicinal chemist's guide to molecular interactions

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3 June 2018

The many roles for fluorine in medicinal chemistry

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3 June 2018

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994063

3 June 2018

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

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3 June 2018

Orthogonal multipolar interactions in structural chemistry and biology

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994063

3 June 2018

Fluorine in medicinal chemistry

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994063

3 June 2018

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

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Halogenation of drugs enhances membrane binding and permeation

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26 November 2018

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Fluorine as a Hydrogen-Bond Acceptor: Experimental Evidence and Computational Calculations

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12 December 2020

based on heuristic

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https://pubmed.ncbi.nlm.nih.gov/27267810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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