Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants (Q30008993)

21 May 2017

title

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants (English)

1 reference

21 May 2017

6

John R Engen

1 reference

21 May 2017

5

Thomas E Smithgall

1 reference

21 May 2017

Thomas E Wales

1

1 reference

21 May 2017

Jerrod A Poe

series ordinal

2

1 reference

21 May 2017

Lori Emert-Sedlak

series ordinal

3

1 reference

21 May 2017

Christopher R Morgan

series ordinal

4

1 reference

21 May 2017

publication date

31 March 2016

1 reference

Journal of the American Society for Mass Spectrometry

21 May 2017

published in

1 reference

21 May 2017

volume

27

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21 May 2017

issue

6

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21 May 2017

page(s)

1048-1061

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Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment

21 May 2017

cites work

1 reference

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How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

22 May 2017

1 reference

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Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

High-speed and high-resolution UPLC separation at zero degrees Celsius

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Nef: "necessary and enforcing factor" in HIV infection

22 May 2017

1 reference

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Structure--function relationships in HIV-1 Nef.

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Solution structure of a polypeptide from the N terminus of the HIV protein Nef

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Primary structure effects on peptide group hydrogen exchange

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Peptide-column interactions and their influence on back exchange rates in hydrogen/deuterium exchange-MS.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Role of Nef in primate lentiviral immunopathogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Partial unfolding of diverse SH3 domains on a wide timescale

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Live and let die: Nef functions beyond HIV replication

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Solvent accessibility of the thrombin-thrombomodulin interface

3 June 2018

1 reference

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HIV-1 Nef: a critical factor in viral-induced pathogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Refined solution structure and backbone dynamics of HIV-1 Nef.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Primary structure effects on peptide group hydrogen exchange.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865444

Differences in disease progression in a cohort of long-term non-progressors after more than 16 years of HIV-1 infection

3 June 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13361-016-1365-5

Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13361-016-1365-5

Hydrogen Exchange Mass Spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13361-016-1365-5

Extensive Deuterium Back-Exchange in Certain Immobilized Pepsin Columns Used for H/D Exchange Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13361-016-1365-5

Conformational Features of the Full-Length HIV and SIV Nef Proteins Determined by Mass Spectrometry†

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13361-016-1365-5

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

21 January 2018

1 reference

12 December 2020

HIV-1 Nef protein: An invitation to a kill

1 reference

12 December 2020

Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions

1 reference

12 December 2020

Cysteine 138 mutation in HIV-1 Nef from patients with delayed disease progression

1 reference

12 December 2020

Hydrogen exchange-mass spectrometry: optimization of digestion conditions

1 reference

12 December 2020

10.1007/S13361-016-1365-5

Identifiers

DOI

1 reference

Dimensions Publication ID

21 May 2017

1049229087

0 references

PMC publication ID

4865444

0 references

1 reference