Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3. (Q30160092)

8 June 2017

title

Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3. (English)

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8 June 2017

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Yan Du

1

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8 June 2017

Barbara C Böck

2

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8 June 2017

Karen A Schachter

3

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8 June 2017

Mary Chao

4

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8 June 2017

Kathleen A Gallo

5

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8 June 2017

language of work or name

English

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publication date

27 October 2005

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Journal of Biological Chemistry

8 June 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

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8 June 2017

volume

280

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8 June 2017

issue

52

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8 June 2017

page(s)

42984-42993

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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

8 June 2017

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Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

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Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling

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Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

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Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase

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Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

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MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

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A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation

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Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

21 January 2018

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Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylat

21 January 2018

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Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain

21 January 2018

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The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation

21 January 2018

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Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

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Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping

21 January 2018

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Cdc42: new roads to travel

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Multiple roles for Cdc42 in cell regulation

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

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Protein prenyltransferases

21 January 2018

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All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

21 January 2018

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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

21 January 2018

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Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

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Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity

21 January 2018

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The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation

21 January 2018

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Phosphorylation of golgin-160 by mixed lineage kinase 3.

21 January 2018

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A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization

21 January 2018

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

21 January 2018

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The conformational plasticity of protein kinases

21 January 2018

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Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

21 January 2018

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Active and inactive protein kinases: structural basis for regulation

21 January 2018

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Regulation of protein kinases; controlling activity through activation segment conformation

21 January 2018

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Activation of endogenous Cdc42 visualized in living cells

21 January 2018

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Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations

21 January 2018

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Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

21 January 2018

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Imaging activation of two Ras isoforms simultaneously in a single cell.

21 January 2018

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Association of Cdc42/N-WASP/Arp2/3 signaling pathway with Golgi membranes

21 January 2018

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Biology of the p21-activated kinases

21 January 2018

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

21 January 2018

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

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Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components

21 January 2018

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The complexity of Raf-1 regulation

21 January 2018

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Physical association with ras enhances activation of membrane-bound raf (RafCAAX).

21 January 2018

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The RAF proteins take centre stage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M502671200

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Signaling by the germinal center kinase family of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

21 January 2018

Identifiers

DOI

10.1074/JBC.M502671200

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8 June 2017

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