Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex (Q30275663)

28 October 2017

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex (English)

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cryogenic electron microscopy

28 October 2017

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author

Katryn J. Stacey

11

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28 October 2017

12

Edward H Egelman

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28 October 2017

9

Pawel A Penczek

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28 October 2017

Tian-Min Fu

1

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28 October 2017

Yang Li

2

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28 October 2017

Alvin Lu

3

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28 October 2017

Zongli Li

4

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28 October 2017

Parimala R Vajjhala

5

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28 October 2017

Anthony C Cruz

6

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28 October 2017

Devendra B Srivastava

7

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28 October 2017

Frank DiMaio

8

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28 October 2017

Richard M Siegel

10

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28 October 2017

Hao Wu

13

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28 October 2017

12 October 2016

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28 October 2017

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28 October 2017

64

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28 October 2017

2

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28 October 2017

236-250

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Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

28 October 2017

1 reference

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3 June 2018

1 reference

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Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain

3 June 2018

1 reference

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3 June 2018

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3 June 2018

1 reference

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Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

3 June 2018

1 reference

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3 June 2018

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A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death

3 June 2018

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Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model

3 June 2018

1 reference

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The tandem CARDs of NOD2: intramolecular interactions and recognition of RIP2.

3 June 2018

1 reference

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Helical assembly in the death domain (DD) superfamily

3 June 2018

1 reference

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

3 June 2018

1 reference

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089849

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089849

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089849

Reconstruction of Helical Filaments and Tubes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089849

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

3 June 2018

1 reference

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Mechanism of procaspase-8 activation by c-FLIPL

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089849

The many roles of FAS receptor signaling in the immune system

3 June 2018

1 reference

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

3 June 2018

1 reference

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3 June 2018

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Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

3 June 2018

1 reference

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Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

3 June 2018

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SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane

3 June 2018

1 reference

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1 reference

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3 June 2018

1 reference

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1 reference

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1 reference

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3 June 2018

1 reference

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3 June 2018

1 reference

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Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

3 June 2018

1 reference

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NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

3 June 2018

1 reference

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3 June 2018

1 reference

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3 June 2018

1 reference

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3 June 2018

1 reference

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26 November 2018

1 reference

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1 reference

12 December 2020

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1 reference

12 December 2020

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1 reference

12 December 2020

10.1016/J.MOLCEL.2016.09.009

Identifiers

DOI

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28 October 2017

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28 October 2017

PubMed publication ID

27746017

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